Detailed view for TVAG_153470

Basic information

TDR Targets ID: 851068
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 6.4374 | Length (AA): 369 | MW (Da): 42824 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04433   SWIRM domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127525)

Species Accession Gene Product
Arabidopsis thaliana AT4G34430   SWI/SNF complex subunit SWI3D
Arabidopsis thaliana AT1G21700   SWI/SNF complex subunit SWI3C
Arabidopsis thaliana AT2G33610   switch subunit 3
Arabidopsis thaliana AT2G47620   SWI/SNF complex subunit SWI3A
Brugia malayi Bm1_20550   SWIRM domain containing protein
Candida albicans CaO19.4488   General RNA polymerase II transcription factor
Candida albicans CaO19.11964   General RNA polymerase II transcription factor
Candida albicans CaO19.7234   similar to eighth largest subunit (RSC8) of S. cerevisiae nucleosome remodeling complex
Caenorhabditis elegans CELE_Y113G7B.23   Protein SWSN-1, isoform B
Cryptosporidium hominis Chro.20189   erythrocyte membrane protein PFEMP3
Cryptosporidium parvum cgd2_1740   RSC8 ortholog with a swirm domain, ZZ finger and Myb
Dictyostelium discoideum DDB_G0277033   SWIRM domain-containing protein
Drosophila melanogaster Dmel_CG18740   moira
Echinococcus granulosus EgrG_001118700   SWI:SNF complex subunit SMARCC2
Echinococcus multilocularis EmuJ_001118700   SWI:SNF complex subunit SMARCC2
Homo sapiens ENSG00000139613   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Homo sapiens ENSG00000173473   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Loa Loa (eye worm) LOAG_04430   hypothetical protein
Mus musculus ENSMUSG00000032481   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Mus musculus ENSMUSG00000025369   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Neospora caninum NCLIV_013840   hypothetical protein
Oryza sativa 4336176   Os04g0480300
Oryza sativa 4349954   Os11g0183700
Oryza sativa 4328597   Os02g0194000
Oryza sativa 9266524   Os12g0176600
Oryza sativa 4334928   Os04g0110300
Saccharomyces cerevisiae YFR037C   Rsc8p
Saccharomyces cerevisiae YJL176C   Swi3p
Schistosoma japonicum Sjp_0076870   SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2, putative
Schistosoma mansoni Smp_152650   SWI/SNF complex-related
Schmidtea mediterranea mk4.002006.06   Brahma associated protein 155 kDa
Schmidtea mediterranea mk4.035810.01   Brahma associated protein 155 kDa
Schmidtea mediterranea mk4.034641.00   Brahma associated protein 155 kDa
Schmidtea mediterranea mk4.035810.02   Brahma associated protein 155 kDa
Schmidtea mediterranea mk4.034641.01   Brahma associated protein 155 kDa
Schmidtea mediterranea mk4.002752.01   SWI/SNF complex subunit SMARCC-1
Toxoplasma gondii TGME49_286920   SWIRM domain-containing protein
Theileria parva TP03_0714   hypothetical protein
Trichomonas vaginalis TVAG_288520   conserved hypothetical protein
Trichomonas vaginalis TVAG_002270   conserved hypothetical protein
Trichomonas vaginalis TVAG_153470   conserved hypothetical protein

Essentiality

TVAG_153470 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y113G7B.23 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y113G7B.23 Caenorhabditis elegans larval arrest wormbase
CELE_Y113G7B.23 Caenorhabditis elegans larval lethal wormbase
CELE_Y113G7B.23 Caenorhabditis elegans slow growth wormbase
CELE_Y113G7B.23 Caenorhabditis elegans sterile wormbase
YFR037C Saccharomyces cerevisiae inviable yeastgenome
TGME49_286920 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_153470 (Trichomonas vaginalis), conserved hypothetical protein
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