Detailed view for TVAG_281170

Basic information

TDR Targets ID: 857352
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 6.3542 | Length (AA): 2766 | MW (Da): 315786 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129916)

Species Accession Gene Product
Echinococcus granulosus EgrG_000510300   hypothetical protein
Echinococcus multilocularis EmuJ_000510300   hypothetical protein
Homo sapiens ENSG00000205081   chromosome X open reading frame 30
Homo sapiens ENSG00000165164   chromosome X open reading frame 22
Leishmania braziliensis LbrM.22.1530   hypothetical protein, conserved
Leishmania donovani LdBPK_221470.1   hypothetical protein, conserved
Leishmania infantum LinJ.22.1470   hypothetical protein, conserved
Leishmania major LmjF.22.1620   hypothetical protein, conserved
Leishmania mexicana LmxM.22.1620   hypothetical protein, conserved
Mus musculus ENSMUSG00000079517   predicted gene 8787
Mus musculus ENSMUSG00000073077   predicted gene 7173
Mus musculus 636082   predicted gene 16462
Schistosoma japonicum Sjp_0096670   Conserved hypothetical protein
Schistosoma japonicum Sjp_0020190   Conserved hypothetical protein
Schistosoma mansoni Smp_086000   hypothetical protein
Schmidtea mediterranea mk4.015531.02  
Schmidtea mediterranea mk4.010040.03  
Schmidtea mediterranea mk4.013290.01  
Schmidtea mediterranea mk4.015082.00  
Schmidtea mediterranea mk4.015082.04  
Schmidtea mediterranea mk4.017098.00  
Schmidtea mediterranea mk4.010040.02  
Schmidtea mediterranea mk4.015531.01  
Trypanosoma brucei gambiense Tbg972.6.310   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.620   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_6_140   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511827.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510535.20   hypothetical protein, conserved
Trichomonas vaginalis TVAG_281170   conserved hypothetical protein
Trichomonas vaginalis TVAG_051730   conserved hypothetical protein
Trichomonas vaginalis TVAG_473440   conserved hypothetical protein
Trichomonas vaginalis TVAG_533970   conserved hypothetical protein
Trichomonas vaginalis TVAG_379040   conserved hypothetical protein
Trichomonas vaginalis TVAG_373180   conserved hypothetical protein
Trichomonas vaginalis TVAG_259310   conserved hypothetical protein

Essentiality

TVAG_281170 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.620 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.620 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.620 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.620 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_281170 (Trichomonas vaginalis), conserved hypothetical protein
Title for this comment
Comment