Detailed view for TVAG_190450

Basic information

TDR Targets ID: 865718
Trichomonas vaginalis, kakapo, putative
Source Database / ID: 

pI: 4.659 | Length (AA): 931 | MW (Da): 106258 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00307   Calponin homology (CH) domain
PF13405   EF-hand domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128602)

Species Accession Gene Product
Brugia malayi Bm1_51465   alpha-actinin
Caenorhabditis elegans CELE_W04D2.1   Protein ATN-1, isoform C
Dictyostelium discoideum DDB_G0268632   actin binding protein A
Drosophila melanogaster Dmel_CG4376   alpha actinin
Echinococcus granulosus EgrG_001096300   alpha actinin sarcomeric
Echinococcus granulosus EgrG_000856100   alpha actinin sarcomeric
Entamoeba histolytica EHI_199000   calponin homology domain protein, putative
Echinococcus multilocularis EmuJ_000856100   alpha actinin, sarcomeric
Echinococcus multilocularis EmuJ_001096300   alpha actinin, sarcomeric
Homo sapiens ENSG00000072110   actinin, alpha 1
Homo sapiens 81   actinin, alpha 4
Homo sapiens ENSG00000077522   actinin, alpha 2
Loa Loa (eye worm) LOAG_08734   alpha-actinin
Loa Loa (eye worm) LOAG_10741   hypothetical protein
Mus musculus ENSMUSG00000052374   actinin alpha 2
Mus musculus ENSMUSG00000015143   actinin, alpha 1
Mus musculus ENSMUSG00000054808   actinin alpha 4
Mus musculus ENSMUSG00000006457   actinin alpha 3
Schistosoma japonicum Sjp_0086910   ko:K05699 actinin alpha, putative
Schistosoma japonicum Sjp_0118260   Alpha-actinin, sarcomeric, putative
Schistosoma japonicum Sjp_0059270   Alpha-actinin-1, putative
Schistosoma japonicum Sjp_0310450   Alpha-actinin, sarcomeric, putative
Schistosoma japonicum Sjp_0105890   Alpha-actinin, sarcomeric, putative
Schistosoma mansoni Smp_034550   alpha-actinin
Schistosoma mansoni Smp_014780.1   alpha-actinin
Schistosoma mansoni Smp_014780.2   alpha-actinin
Schmidtea mediterranea mk4.013143.01  
Schmidtea mediterranea mk4.011730.00  
Schmidtea mediterranea mk4.008854.00  
Schmidtea mediterranea mk4.004376.00  
Schmidtea mediterranea mk4.006136.00  
Schmidtea mediterranea mk4.015134.00  
Schmidtea mediterranea mk4.012882.00  
Schmidtea mediterranea mk4.002344.00  
Schmidtea mediterranea mk4.005366.02  
Schmidtea mediterranea mk4.032913.00  
Schmidtea mediterranea mk4.008854.01  
Schmidtea mediterranea mk4.027393.01  
Schmidtea mediterranea mk4.018845.00  
Schmidtea mediterranea mk4.018281.00  
Schmidtea mediterranea mk4.027393.00  
Schmidtea mediterranea mk4.012882.01  
Trichomonas vaginalis TVAG_239310   bollus pemphigoid antigen, putative
Trichomonas vaginalis TVAG_190450   kakapo, putative
Trichomonas vaginalis TVAG_190470   hypothetical protein
Trichomonas vaginalis TVAG_156680   vab10 spectraplakin, putative

Essentiality

TVAG_190450 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_W04D2.1 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Calmodulin 149 aa 24.0% 121 aa Compounds References
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0016 0.2966 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_190450 (Trichomonas vaginalis), kakapo, putative
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