pI: 8.031 |
Length (AA): 353 |
MW (Da): 41156 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128263)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G10270 | 1 |
Arabidopsis thaliana | AT5G64960 | cyclin-dependent kinase C-2 |
Brugia malayi | Bm1_46210 | Protein kinase domain containing protein |
Candida albicans | CaO19.1619 | Rpo21 C-terminus domain kinase |
Candida albicans | CaO19.9187 | Rpo21 C-terminus domain kinase |
Caenorhabditis elegans | CELE_B0285.1 | Protein CDK-12, isoform B |
Dictyostelium discoideum | DDB_G0273207 | CDK family protein kinase |
Dictyostelium discoideum | DDB_G0273721 | CDK family protein kinase |
Drosophila melanogaster | Dmel_CG7597 | CG7597 gene product from transcript CG7597-RB |
Echinococcus granulosus | EgrG_001041300 | Cell division cycle 2 protein kinase |
Echinococcus multilocularis | EmuJ_001041300 | Cell division cycle 2 protein kinase |
Homo sapiens | ENSG00000065883 | cyclin-dependent kinase 13 |
Homo sapiens | ENSG00000167258 | cyclin-dependent kinase 12 |
Loa Loa (eye worm) | LOAG_03355 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04967 | CMGC/CDK/CRK7 protein kinase |
Mus musculus | ENSMUSG00000041297 | cyclin-dependent kinase 13 |
Mus musculus | ENSMUSG00000003119 | cyclin-dependent kinase 12 |
Neospora caninum | NCLIV_023400 | hypothetical protein |
Oryza sativa | 9268645 | Os08g0453800 |
Oryza sativa | 4338674 | Os05g0389700 |
Oryza sativa | 4325386 | Os01g0958000 |
Saccharomyces cerevisiae | YKL139W | Ctk1p |
Schistosoma japonicum | Sjp_0094410 | Cell division cycle 2-like protein kinase 5, putative |
Schistosoma japonicum | Sjp_0094420 | ko:K08819 Cdc2-related kinase, arginine/serine-rich, putative |
Schistosoma mansoni | Smp_007510 | protein kinase |
Schmidtea mediterranea | mk4.000235.06 | Cyclin-dependent kinase 12 |
Schmidtea mediterranea | mk4.004836.01 | |
Schmidtea mediterranea | mk4.012172.00 | Cyclin-dependent kinase 12 |
Toxoplasma gondii | TGME49_281450 | cell-cycle-associated protein kinase, putative |
Trichomonas vaginalis | TVAG_359930 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_249190 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_265810 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_235250 | CMGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_B0285.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0285.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_B0285.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_B0285.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_B0285.1 | Caenorhabditis elegans | sterile | wormbase |
YKL139W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_281450 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 12 | Compounds | References |
Homo sapiens | cyclin-dependent kinase 13 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 39.8% | 186 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 39.3% | 295 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 25.7% | 307 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 26.7% | 180 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 40.3% | 293 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 39.9% | 293 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 40.3% | 290 aa | Compounds | References |