Detailed view for TVAG_117900

Basic information

TDR Targets ID: 876289
Trichomonas vaginalis, synaptotagmin, putative
Source Database / ID: 

pI: 9.5785 | Length (AA): 125 | MW (Da): 14330 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138081)

Species Accession Gene Product
Arabidopsis thaliana AT5G50170   C2 and GRAM domain-containing protein
Arabidopsis thaliana AT1G03365   putative E3 ubiquitin-protein ligase RF4
Arabidopsis thaliana AT4G03000   putative E3 ubiquitin-protein ligase RF298
Arabidopsis thaliana AT1G03370   C2 calcium/lipid-binding and GRAM domain containing protein
Oryza sativa 4328641   Os02g0199800
Oryza sativa 4340810   Os06g0297800
Oryza sativa 4345911   Os08g0492400
Oryza sativa 4337764   Os05g0141500
Oryza sativa 4336156   Os04g0476600
Oryza sativa 9269603   Os06g0607900
Trichomonas vaginalis TVAG_117900   synaptotagmin, putative
Trichomonas vaginalis TVAG_160580   synaptotagmin 1, 3, C.elegans, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.005 0.2612 0.5
0.0072 0.2639 1
0.0018 0.5 0.5
0.0071 0.2549 0.5
0.0058 0.5 0.5
0.0125 0.3893 0.3893
0.0109 0.4866 0.5
0.0107 0.5 0.5
0.0121 1 1
0.0057 0.3491 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_117900 (Trichomonas vaginalis), synaptotagmin, putative
Title for this comment
Comment