Detailed view for TVAG_066800

Basic information

TDR Targets ID: 894803
Trichomonas vaginalis, ubiquitin-conjugating enzyme E2 j2, putative
Source Database / ID: 

pI: 4.2026 | Length (AA): 344 | MW (Da): 38865 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00179   Ubiquitin-conjugating enzyme

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128898)

Species Accession Gene Product
Arabidopsis thaliana AT3G17000   ubiquitin-conjugating enzyme E2 32
Caenorhabditis elegans CELE_D1022.1   Protein UBC-6, isoform B
Cryptosporidium hominis Chro.80443   hypothetical protein
Cryptosporidium parvum cgd8_3850   Ubc6p like ubiquiting conjugating enzyme E2, possible transmembrane domain at C
Dictyostelium discoideum DDB_G0281369   hypothetical protein
Echinococcus granulosus EgrG_000406600   Ubiquitin conjugating enzyme E2 J1
Entamoeba histolytica EHI_049740   ubiquitin-conjugating enzyme family protein
Echinococcus multilocularis EmuJ_000406600   Ubiquitin conjugating enzyme E2 J1
Giardia lamblia GL50803_5921   Ubiquitin-conjugating enzyme E2-28.4 kDa
Homo sapiens ENSG00000198833   ubiquitin-conjugating enzyme E2, J1
Leishmania braziliensis LbrM.05.0910   ubiquitin-conjugating enzyme, putative
Leishmania donovani LdBPK_050930.1   ubiquitin-conjugating enzyme E2, putative
Leishmania infantum LinJ.05.0930   ubiquitin-conjugating enzyme, putative
Leishmania major LmjF.05.0930   ubiquitin-conjugating enzyme, putative
Leishmania mexicana LmxM.05.0930   ubiquitin-conjugating enzyme, putative
Loa Loa (eye worm) LOAG_05499   hypothetical protein
Mus musculus ENSMUSG00000028277   ubiquitin-conjugating enzyme E2J 1
Neospora caninum NCLIV_067330   ubiquitin-conjugating enzyme e2, putative
Oryza sativa 4332614   Os03g0308000
Schistosoma japonicum Sjp_0212120   ko:K10578 ubiquitin-conjugating enzyme E2 J1, putative
Schistosoma japonicum Sjp_0310290   expressed protein
Schistosoma mansoni Smp_174670   non-canonical ubiquitin conjugating enzyme
Schmidtea mediterranea mk4.001680.02   Ubiquitin-conjugating enzyme E2 J1
Trypanosoma brucei gambiense Tbg972.7.8160   ubiquitin-conjugating enzyme, putative,non-canonical ubiquiting-conjugating enzyme 1, putative
Trypanosoma brucei Tb927.7.6960   ubiquitin-conjugating enzyme E2, putative
Trypanosoma congolense TcIL3000_0_44030   ubiquitin-conjugating enzyme E2, putative
Trypanosoma cruzi TcCLB.508387.100   ubiquitin-conjugating enzyme E2, putative
Trypanosoma cruzi TcCLB.506789.200   ubiquitin-conjugating enzyme E2, putative
Toxoplasma gondii TGME49_278670   ubiquitin-conjugating enzyme subfamily protein
Trichomonas vaginalis TVAG_066800   ubiquitin-conjugating enzyme E2 j2, putative
Trichomonas vaginalis TVAG_091080   non-canonical ubiquitin conjugating enzyme, putative

Essentiality

TVAG_066800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.6960 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.6960 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.6960 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.6960 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_D1022.1 Caenorhabditis elegans larval arrest wormbase
CELE_D1022.1 Caenorhabditis elegans slow growth wormbase
TGME49_278670 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_066800 (Trichomonas vaginalis), ubiquitin-conjugating enzyme E2 j2, putative
Title for this comment
Comment