pI: 4.7976 |
Length (AA): 167 |
MW (Da): 18436 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126922)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G69410 | eukaryotic translation initiation factor 5A-3 |
Arabidopsis thaliana | AT1G13950 | translation initiation factor eIF-5A |
Arabidopsis thaliana | AT1G26630 | eukaryotic translation initiation factor 5A-2 |
Babesia bovis | BBOV_IV008910 | translation initiation factor 5A, putative |
Brugia malayi | Bm1_57565 | Eukaryotic translation initiation factor 5A-2 |
Candida albicans | CaO19.10930 | similar to both S. cerevisiae versions of hypusine-containing translation initiation factor eIF-5A, putative sensor of intracell |
Candida albicans | CaO19.3426 | similar to both S. cerevisiae versions of hypusine-containing translation initiation factor eIF-5A, putative sensor of intracell |
Caenorhabditis elegans | CELE_F54C9.1 | Protein IFF-2 |
Caenorhabditis elegans | CELE_T05G5.10 | Protein IFF-1, isoform C |
Cryptosporidium hominis | Chro.70262 | translation initiation factor 5A2 |
Cryptosporidium parvum | cgd7_2300 | translation initiation factor if-5A |
Dictyostelium discoideum | DDB_G0284861 | eukaryotic translation initiation factor 5A |
Drosophila melanogaster | Dmel_CG3186 | CG3186 gene product from transcript CG3186-RB |
Echinococcus granulosus | EgrG_000749800 | eukaryotic translation initiation factor 5A |
Entamoeba histolytica | EHI_186480 | translation initiation factor eIF-5A, putative |
Entamoeba histolytica | EHI_177460 | translation initiation factor eIF-5A, putative |
Entamoeba histolytica | EHI_151540 | translation initiation factor eIF-5A, putative |
Entamoeba histolytica | EHI_151810 | translation initiation factor eIF-5A, putative |
Echinococcus multilocularis | EmuJ_000749800 | eukaryotic translation initiation factor 5A |
Giardia lamblia | GL50803_14614 | Eukaryotic translation initiation factor 5A |
Homo sapiens | ENSG00000132507 | eukaryotic translation initiation factor 5A |
Homo sapiens | ENSG00000163577 | eukaryotic translation initiation factor 5A2 |
Homo sapiens | ENSG00000253626 | eukaryotic translation initiation factor 5A-like 1 |
Leishmania braziliensis | LbrM.25.0580 | eukaryotic initiation factor 5a, putative |
Leishmania braziliensis | LbrM.25.0590 | eukaryotic initiation factor 5a, putative |
Leishmania braziliensis | LbrM.25.0600 | eukaryotic initiation factor 5a, putative |
Leishmania braziliensis | LbrM.25.0610 | eukaryotic initiation factor 5a, putative |
Leishmania donovani | LdBPK_250740.1 | eukaryotic initiation factor 5a, putative |
Leishmania donovani | LdBPK_250750.1 | eukaryotic initiation factor 5a, putative |
Leishmania infantum | LinJ.25.0750 | eukaryotic initiation factor 5a, putative |
Leishmania infantum | LinJ.25.0760 | eukaryotic initiation factor 5a, putative |
Leishmania infantum | LinJ.25.0740 | eukaryotic initiation factor 5a, putative |
Leishmania major | LmjF.25.0720 | eukaryotic initiation factor 5a, putative |
Leishmania major | LmjF.25.0730 | eukaryotic initiation factor 5a, putative |
Leishmania mexicana | LmxM.25.0730 | eukaryotic initiation factor 5a, putative |
Leishmania mexicana | LmxM.25.0720 | eukaryotic initiation factor 5a, putative |
Loa Loa (eye worm) | LOAG_01764 | eukaryotic translation initiation factor 5A-2 |
Mus musculus | ENSMUSG00000078812 | eukaryotic translation initiation factor 5A |
Mus musculus | ENSMUSG00000050192 | eukaryotic translation initiation factor 5A2 |
Neospora caninum | NCLIV_066870 | hypothetical protein |
Oryza sativa | 4342241 | Os07g0112800 |
Oryza sativa | 4343796 | Os07g0597000 |
Oryza sativa | 9268063 | Os07g0236250 |
Oryza sativa | 4352300 | Os12g0507200 |
Oryza sativa | 4334177 | Os03g0758800 |
Onchocerca volvulus | OVOC11437 | Eukaryotic translation initiation factor 5A homolog |
Plasmodium berghei | PBANKA_0603200 | eukaryotic translation initiation factor 5A, putative |
Plasmodium falciparum | PF3D7_1204300 | eukaryotic translation initiation factor 5A |
Plasmodium knowlesi | PKNH_1304000 | eukaryotic translation initiation factor 5A, putative |
Plasmodium vivax | PVX_084255 | eukaryotic translation initiation factor 5A |
Plasmodium yoelii | PY00983 | translation initiation factor eIF-5A |
Saccharomyces cerevisiae | YJR047C | translation elongation factor eIF-5A |
Saccharomyces cerevisiae | YEL034W | translation elongation factor eIF-5A |
Schistosoma japonicum | Sjp_0017450 | ko:K03263 translation initiation factor eIF-5A, putative |
Schistosoma mansoni | Smp_039400 | initiation factor 5a |
Schmidtea mediterranea | mk4.004989.01 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.004632.01 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.001678.01 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.003167.00 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.006418.02 | Eukaryotic translation initiation factor 5A |
Schmidtea mediterranea | mk4.002434.00 | Eukaryotic translation initiation factor 5A |
Trypanosoma brucei gambiense | Tbg972.11.740 | eukaryotic translation initiation factor 5a, putative |
Trypanosoma brucei | Tb927.11.740 | eukaryotic translation initiation factor 5A |
Trypanosoma cruzi | TcCLB.506925.120 | eukaryotic translation initiation factor 5A |
Trypanosoma cruzi | TcCLB.506925.130 | eukaryotic translation initiation factor 5A |
Toxoplasma gondii | TGME49_251810 | translation initiation factor eIF-5A, putative |
Theileria parva | TP01_0884 | eukaryotic translation initiation factor 5A, putative |
Trichomonas vaginalis | TVAG_361780 | initiation factor 5A, putative |
Trichomonas vaginalis | TVAG_283020 | initiation factor 5A, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.03.0410 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.03.0410 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.03.0410 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.03.0410 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T05G5.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T05G5.10 | Caenorhabditis elegans | sterile | wormbase |
CELE_F54C9.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F54C9.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F54C9.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F54C9.1 | Caenorhabditis elegans | sterile | wormbase |
YEL034W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_251810 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.