Detailed view for TVAG_498850

Basic information

TDR Targets ID: 910222
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 5.5819 | Length (AA): 1308 | MW (Da): 148998 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF15625   CC2D2A N-terminal C2 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131027)

Species Accession Gene Product
Brugia malayi Bm1_54540   RIKEN cDNA 5730509K17 gene
Caenorhabditis elegans CELE_K07G5.3   Protein MKS-6
Drosophila melanogaster Dmel_CG43370   CG43370 gene product from transcript CG43370-RD
Homo sapiens ENSG00000048342   coiled-coil and C2 domain containing 2A
Loa Loa (eye worm) LOAG_16321   hypothetical protein
Loa Loa (eye worm) LOAG_10780   hypothetical protein
Mus musculus 668310   coiled-coil and C2 domain containing 2B
Mus musculus ENSMUSG00000039765   coiled-coil and C2 domain containing 2A
Schistosoma japonicum Sjp_0103970   hypothetical protein
Schistosoma japonicum Sjp_0130900   hypothetical protein
Schistosoma mansoni Smp_143910   hypothetical protein
Trichomonas vaginalis TVAG_239170   hypothetical protein
Trichomonas vaginalis TVAG_498850   conserved hypothetical protein
Trichomonas vaginalis TVAG_474970   conserved hypothetical protein
Trichomonas vaginalis TVAG_443100   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0107 0.5 0.5
0.0125 0.3893 0.3893
0.0018 0.5 0.5
0.0071 0.2549 0.5
0.0109 0.4866 0.5
0.0057 0.3491 0.5
0.0072 0.2639 1
0.0058 0.5 0.5
0.005 0.2612 0.5
0.0121 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_498850 (Trichomonas vaginalis), conserved hypothetical protein
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