Detailed view for TVAG_071140

Basic information

TDR Targets ID: 913034
Trichomonas vaginalis, clathrin coat assembly protein ap17, putative
Source Database / ID: 

pI: 5.2243 | Length (AA): 141 | MW (Da): 16705 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01217   Clathrin adaptor complex small chain

Gene Ontology

Mouse over links to read term descriptions.
GO:0015031   protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130491)

Species Accession Gene Product
Arabidopsis thaliana AT2G19790   SNARE-like superfamily protein
Babesia bovis BBOV_IV010980   clathrin assembly protein small subunit, putative
Cryptosporidium parvum cgd8_4900   clathrin assembly protein, putative
Dictyostelium discoideum DDB_G0284905   adapter-related protein complex 4 sigma 1 subunit
Entamoeba histolytica EHI_045190   clathrin adaptor complex small chain, putative
Homo sapiens ENSG00000100478   adaptor-related protein complex 4, sigma 1 subunit
Mus musculus ENSMUSG00000020955   adaptor-related protein complex AP-4, sigma 1
Neospora caninum NCLIV_057490   AP-4 complex subunit sigma-1, putative
Oryza sativa 4345488   Os08g0395300
Oryza sativa 4348463   Os10g0368400
Plasmodium berghei PBANKA_0523500   AP-4 complex subunit sigma, putative
Plasmodium falciparum PF3D7_0423100   AP-4 complex subunit sigma, putative
Plasmodium knowlesi PKNH_0515000   AP-4 complex subunit sigma, putative
Plasmodium vivax PVX_090195   AP-4 complex subunit sigma, putative
Plasmodium yoelii PY06451   putative clathrin assembly protein
Trypanosoma brucei gambiense Tbg972.10.16660   clathrin assembly sigma-adaptin protein complex 4, putative
Trypanosoma brucei Tb927.10.14260   AP-4 complex subunit sigma-1, putative
Trypanosoma cruzi TcCLB.506525.104   AP-4 complex subunit sigma-1, putative
Trypanosoma cruzi TcCLB.511283.109   AP-4 complex subunit sigma-1, putative
Toxoplasma gondii TGME49_314418   clathrin adaptor complex small chain family protein
Theileria parva TP01_0763   clathrin assembly protein, putative
Trichomonas vaginalis TVAG_071140   clathrin coat assembly protein ap17, putative
Trichomonas vaginalis TVAG_283330   clathrin coat assembly protein ap19, putative

Essentiality

TVAG_071140 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14260 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14260 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.14260 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.14260 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_314418 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_071140 (Trichomonas vaginalis), clathrin coat assembly protein ap17, putative
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