Detailed view for TVAG_340730

Basic information

TDR Targets ID: 925826
Trichomonas vaginalis, DTDP-4-dehydrorhamnose 3,5-epimerase, putative
Source Database / ID: 

pI: 5.1263 | Length (AA): 347 | MW (Da): 38926 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00908   dTDP-4-dehydrorhamnose 3,5-epimerase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008830   dTDP-4-dehydrorhamnose 3,5-epimerase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132926)

Species Accession Gene Product
Brugia malayi Bm1_32635   dTDP-4-dehydrorhamnose 3,5-epimerase
Caenorhabditis elegans CELE_C14F11.6   Protein C14F11.6
Escherichia coli b2038   dTDP-4-deoxyrhamnose-3,5-epimerase
Loa Loa (eye worm) LOAG_00105   dTDP-4-dehydrorhamnose 3,5-epimerase
Mycobacterium leprae ML1965   dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIP
Mycobacterium tuberculosis Rv3465   dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine dip
Mycobacterium ulcerans MUL_0839   dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC
Onchocerca volvulus OVOC3044  
Schmidtea mediterranea mk4.040374.01  
Schmidtea mediterranea mk4.059329.02  
Trichomonas vaginalis TVAG_313960   conserved hypothetical protein
Trichomonas vaginalis TVAG_340730   DTDP-4-dehydrorhamnose 3,5-epimerase, putative

Essentiality

TVAG_340730 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3526 Mycobacterium tuberculosis essential nmpdr
b2038 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine dip Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0289 0.2689 1
0.0373956 1 1
0.0314 0.2764 1
0.0274 0.2689 1
0.0314 0.2764 1
0.0305 0.3227 1
0.0291 0.2854 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_340730 (Trichomonas vaginalis), DTDP-4-dehydrorhamnose 3,5-epimerase, putative
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