Detailed information for compound 1115872

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.957 | Formula: C26H26ClN3O
  • H donors: 1 H acceptors: 1 LogP: 5.6 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CN(Cc1ccc(cc1)CNc1ccnc2c1ccc(c2)Cl)C
  • InChi: 1S/C26H26ClN3O/c1-30(18-21-7-10-23(31-2)11-8-21)17-20-5-3-19(4-6-20)16-29-25-13-14-28-26-15-22(27)9-12-24(25)26/h3-15H,16-18H2,1-2H3,(H,28,29)
  • InChiKey: HLGFJLRGCHAVQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis pyruvate kinase 0.0035 0.0069 0.474
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0053 0.0246
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.2001 1
Schistosoma mansoni hypothetical protein 0.0146 0.0403 0.2013
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0029 0.0159
Schistosoma mansoni loxhd1 0.0019 0.0023 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0183 0.2107
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0029 0.0753
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0038 0.1385
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0059 0.0295
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0029 0.1532
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.006 0.03
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0029 0.0056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0105 0.0279 0.1326
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0164 0.0779
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0059 0.0277
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0029 0.0056
Mycobacterium tuberculosis Probable reductase 0.0113 0.0305 0.2142
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0023 0.0081
Brugia malayi steroid hormone receptor 0.0031 0.0059 0.0277
Echinococcus granulosus pyruvate kinase 0.0035 0.0069 0.0248
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.015 0.015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0059 0.0211
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0024 0.0489
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0029 0.0133
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0029 0.0159
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0029 0.0754
Brugia malayi topoisomerase 0.002 0.0024 0.0112
Echinococcus multilocularis pyruvate kinase 0.0028 0.0047 0.0047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0305 0.3568
Entamoeba histolytica hypothetical protein 0.0146 0.0403 0.7027
Echinococcus granulosus neuropeptide s receptor 0.0941 0.2793 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0159 0.0159
Mycobacterium ulcerans dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC 0.0281 0.081 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0023 0.0113
Leishmania major trypanothione reductase 0.005 0.0114 0.5827
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0069 0.0326
Echinococcus granulosus lamin 0.0055 0.0129 0.0461
Onchocerca volvulus 0.0248 0.071 0.8765
Brugia malayi glutathione reductase 0.005 0.0114 0.0537
Loa Loa (eye worm) hypothetical protein 0.0199 0.0563 0.2679
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0115 0.0115
Brugia malayi nuclear hormone receptor 0.0015 0.0009 0.004
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0226 0.0226
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0018 0.1371
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0183 0.2107
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0069 0.0394
Onchocerca volvulus 0.0021 0.0029 0.0346
Schistosoma mansoni hypothetical protein 0.0173 0.0483 0.2415
Entamoeba histolytica hypothetical protein 0.0146 0.0403 0.7027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Wolbachia endosymbiont of Brugia malayi nucleoside-diphosphate-sugar epimerase 0.0069 0.0173 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0059 0.0277
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0023 0.0081
Schistosoma mansoni zinc finger protein 0.0015 0.0009 0.0046
Schistosoma mansoni hypothetical protein 0.0082 0.0212 0.106
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0029 0.0159
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0009 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0009 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0103
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.0403 0.1442
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0183 0.2107
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0029 0.0094
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0044 0.1642
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0009 0.0046
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0023 0.0104
Onchocerca volvulus 0.0073 0.0183 0.2257
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0164 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0383 0.1915
Loa Loa (eye worm) glutathione reductase 0.005 0.0114 0.0537
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0029 0.2198
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0023 0.1198
Onchocerca volvulus 0.0019 0.0023 0.027
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0009 0.0033
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0115 0.6246
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0183 0.2107
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0024 0.0469
Brugia malayi ecdysteroid receptor 0.0031 0.0059 0.0277
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0024 0.0112
Schistosoma mansoni lamin 0.0055 0.0129 0.0643
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0305 0.2142
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0024 0.0024
Giardia lamblia Pyruvate kinase 0.0035 0.0069 0.5375
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0711 0.2101 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0059 0.072
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0009 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0059 0.0211
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0014 0.0065
Schistosoma mansoni cpg binding protein 0.0031 0.0056 0.0281
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0024 0.129
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0183 0.087
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0226 0.107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0164 0.0821
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.019
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0059 0.0277
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0059 0.0059
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0038 0.1299
Onchocerca volvulus 0.0373956 1 0.5
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0029 0.0753
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0059 0.0211
Leishmania major hypothetical protein, conserved 0.0073 0.0183 0.9999
Onchocerca volvulus 0.0073 0.0183 0.2257
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0009 0.0103
Echinococcus multilocularis pyruvate kinase 0.0035 0.0069 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0024 0.0489
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0029 0.0159
Echinococcus multilocularis musashi 0.0055 0.0129 0.0129
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0029 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0029 0.0159
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0024 0.0093
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0059 0.0277
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0029 0.0159
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0183 0.0183
Brugia malayi hypothetical protein 0.002 0.0024 0.0112
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0305 0.2142
Echinococcus granulosus RUN 0.0019 0.0023 0.0081
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.0283
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0159 0.0755
Brugia malayi nuclear receptor NHR-88 0.0015 0.0009 0.004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0127 0.0456
Onchocerca volvulus 0.0055 0.0129 0.1581
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0277
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0183 0.1242
Mycobacterium tuberculosis dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine dip 0.0373956 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0029 0.0159
Onchocerca volvulus 0.0145 0.04 0.4935
Toxoplasma gondii ABC1 family protein 0.0073 0.0183 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0029 0.1532
Schistosoma mansoni lipoxygenase 0.0054 0.0127 0.0637
Brugia malayi hypothetical protein 0.0017 0.0016 0.007
Leishmania major pyruvate kinase 0.0035 0.0069 0.3172
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0164 0.0821
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0014 0.0065
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0221 0.0793
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0115 0.0115
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0029 0.0103
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0023 0.0023
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0029 0.1532
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0277
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0077 0.0077
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0183 0.2107
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0029 0.0159
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0343 0.2424
Brugia malayi hypothetical protein 0.002 0.0024 0.0112
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0016 0.0842
Plasmodium vivax SET domain protein, putative 0.0032 0.006 0.3248
Brugia malayi Pre-SET motif family protein 0.0218 0.062 0.2948
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0115 0.5901
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0009 0.004
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0038 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0059 0.0277
Echinococcus granulosus pyruvate kinase 0.0018 0.0018 0.0065
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0024 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0024 0.0489
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0159 0.8558
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0024 0.1245
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.015 0.0996
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.0563 0.0563
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0183 0.087
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0024 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0059 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0183 0.087
Brugia malayi RNA binding protein 0.0066 0.0164 0.0779
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0128 0.697
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0014 0.0065
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0009 0.004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0183 0.2107
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0029 0.0159
Loa Loa (eye worm) hypothetical protein 0.0055 0.0129 0.0609
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0164 0.0821
Echinococcus multilocularis RUN 0.0019 0.0023 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0119 0.0764
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0029 0.0754
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0221 0.1051
Echinococcus granulosus pyruvate kinase 0.0018 0.0018 0.0065
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0053 0.0246
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0087 0.0226 0.107
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0018 0.0956
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0059 0.0295
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0059 0.0277
Onchocerca volvulus 0.0015 0.0009 0.0103
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0059 0.0295
Schistosoma mansoni coup transcription factor 0.0031 0.0059 0.0295
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0069 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0183 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0024 0.3389
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0114 0.0723
Brugia malayi hypothetical protein 0.0026 0.0044 0.0204
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0024 0.0024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0183 0.2025
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0023 0.1719
Loa Loa (eye worm) dTDP-4-dehydrorhamnose 3,5-epimerase 0.0281 0.081 0.3854
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0009 0.004
Brugia malayi TAR-binding protein 0.0066 0.0164 0.0779
Echinococcus multilocularis protein dispatched 1 0.0098 0.0258 0.0258
Schistosoma mansoni cpg binding protein 0.0029 0.0051 0.0256
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.006 0.0215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0059 0.0295
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0009 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0014 0.0072
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0183 0.1242
Loa Loa (eye worm) RNA binding protein 0.0066 0.0164 0.0779
Entamoeba histolytica hypothetical protein 0.002 0.0024 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0183 0.0917
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.006 0.006
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0059 0.0295
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0115 0.0411
Schistosoma mansoni topbp1 0.002 0.0024 0.0122
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0024 0.044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.006 0.006
Onchocerca volvulus 0.0029 0.0051 0.0623
Brugia malayi dTDP-4-dehydrorhamnose 3,5-epimerase 0.0281 0.081 0.3854
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0183 0.2107
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0183 0.2963
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0029 0.0133
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0069 0.0668
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0024 0.0055
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0065
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0159 0.0755
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0055 0.0196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0326
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0129 0.0609
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0009 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0059 0.0277
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0114 0.6178
Onchocerca volvulus 0.0021 0.0029 0.0346
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0038 0.2032
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0183 0.2963
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0044 0.0044
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0069 0.3172
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0183 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0164 0.0821
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0129 0.0609
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0029 0.0159
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0059 0.0211
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0044 0.1642
Echinococcus granulosus replication factor c subunit 1 0.002 0.0024 0.0087
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0128 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0059 0.072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0059 0.0277
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0119 0.0764
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0132 0.7196
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0183 0.087
Onchocerca volvulus 0.0087 0.0226 0.2777
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0024 0.0103
Brugia malayi follicle stimulating hormone receptor 0.0235 0.067 0.3186
Brugia malayi nuclear receptor NHR-67 0.0015 0.0009 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Brugia malayi beta-lactamase family protein 0.0073 0.0183 0.087
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0059 0.0295
Trichomonas vaginalis set domain proteins, putative 0.0248 0.071 0.8741
Echinococcus granulosus geminin 0.0173 0.0483 0.173
Trypanosoma brucei trypanothione reductase 0.005 0.0114 0.5827
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0029 0.0159
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0014 0.0052
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0024 0.0084
Loa Loa (eye worm) hypothetical protein 0.0054 0.0128 0.0606
Echinococcus multilocularis geminin 0.0173 0.0483 0.0483
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0069 0.0326
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0029 0.0159
Brugia malayi nuclear receptor NHR-88 0.0031 0.0059 0.0277
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0059 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0115 0.0574
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0115 0.5901
Brugia malayi intermediate filament protein 0.0055 0.0129 0.0609
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0029 0.0144
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0343 0.4051
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0069 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0059 0.0277
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0016 0.0842
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0038 0.13
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0183 0.1242
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0024 0.129
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0069 0.0846
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0038 0.0161
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.0563 0.2679
Schistosoma mansoni hypothetical protein 0.0173 0.0483 0.2415
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0114 0.0407
Mycobacterium leprae Probable lipase LipE 0.0073 0.0183 0.2025
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0112
Mycobacterium tuberculosis Conserved protein 0.0073 0.0183 0.1242
Onchocerca volvulus 0.0025 0.004 0.0487
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0115 0.5901
Brugia malayi hypothetical protein 0.0017 0.0014 0.0065
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0081
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.04 0.1902
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.015 0.1691
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0009 0.004
Plasmodium falciparum thioredoxin reductase 0.005 0.0114 0.8864
Loa Loa (eye worm) hypothetical protein 0.0054 0.0128 0.0606
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0029 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0183 0.2107
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0009 0.004
Plasmodium falciparum thioredoxin reductase 0.0017 0.0016 0.1208
Onchocerca volvulus Huntingtin homolog 0.0128 0.0349 0.4305
Schistosoma mansoni survival motor neuron protein 0.0145 0.04 0.2
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0038 0.0274
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0024 0.044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0175
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0183 0.2107
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0115 0.5901
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0127 0.0127
Brugia malayi ecdysone receptor 0.0015 0.0009 0.004
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.082 0.082
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0159 0.8558
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0221 0.2585
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0103
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0029 0.0029
Schistosoma mansoni rab6-interacting 0.0019 0.0023 0.0113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0183 0.2107
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0159 0.8558
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0038 0.1942
Schistosoma mansoni nuclear receptor 0.0015 0.0009 0.0046
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0128 1
Echinococcus granulosus nibrin 0.002 0.0024 0.0087
Trichomonas vaginalis DTDP-4-dehydrorhamnose 3,5-epimerase, putative 0.0373956 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0277
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0226 0.0642 0.7884
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0024 0.1787
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0069 0.3172
Brugia malayi hypothetical protein 0.0019 0.0023 0.0104
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0009 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.006 0.03
Loa Loa (eye worm) hypothetical protein 0.0054 0.0128 0.0606
Brugia malayi beta-lactamase 0.0073 0.0183 0.087
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0183 1
Plasmodium falciparum pyruvate kinase 0.0035 0.0069 0.5376
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0059 0.0277
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0016 0.1208
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0009 0.0009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0059 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.015 0.0752
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0059 0.0277
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0069 0.0846
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0044 0.1642
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0029 0.0094
Schistosoma mansoni cpg binding protein 0.0031 0.0056 0.0281
Brugia malayi DKFZp564C0469 protein 0.002 0.0024 0.0112
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0183 0.1242
Brugia malayi Pre-SET motif family protein 0.0032 0.006 0.0283
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0277
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0009 0.0046
Schistosoma mansoni hypothetical protein 0.0019 0.0023 0.0113
Echinococcus granulosus microtubule associated protein 2 0.0678 0.2001 0.7165
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0044 0.3365
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0038 0.0172
Plasmodium falciparum glutathione reductase 0.0017 0.0016 0.1208
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0183 0.2107
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0115 0.1243
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0024 0.044
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0202 0.0572 0.2861
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0024 0.0103
Schistosoma mansoni pyruvate kinase 0.0035 0.0069 0.0346
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0059 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0281 0.081 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0029 0.0094
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0029 0.1532
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.015 0.1691
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Schistosoma mansoni patched 1 0.0086 0.0221 0.1106
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0305 0.2142
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0305 0.2142
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0059 0.0295
Entamoeba histolytica hypothetical protein 0.0146 0.0403 0.7027
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0029 0.0133
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0023 0.0081
Brugia malayi hypothetical protein 0.0019 0.0023 0.0104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Schistosoma mansoni pyruvate kinase 0.0018 0.0018 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0059 0.0277
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0114 0.0537
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0029 0.0094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0152 0.0759
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0024 0.0522
Schistosoma mansoni ap endonuclease 0.002 0.0024 0.0118
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0164 0.0779
Schistosoma mansoni DNA ligase IV 0.002 0.0024 0.0122
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0024 0.0093
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0009 0.0033
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0024 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0029 0.0159
Brugia malayi hypothetical protein 0.0015 0.0009 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0059 0.0277
Trypanosoma brucei protein kinase, putative 0.005 0.0115 0.5901
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0115 0.1243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.006 0.03
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0059 0.0277
Treponema pallidum DNA ligase (lig) 0.002 0.0024 0.3766
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0059 0.0295
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.0563 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0128 0.0606
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0002 0.0008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0029 0.0754
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0038 0.2032
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.12 0.12
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0133
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0114 0.5827
Loa Loa (eye worm) dTDP-4-dehydrorhamnose 3,5-epimerase 0.0373956 1 0.5
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0277
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.006 0.3248
Plasmodium vivax glutathione reductase, putative 0.005 0.0114 0.6178
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0104
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0069 0.0326
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0226 0.1127
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0024 0.0015
Mycobacterium ulcerans hypothetical protein 0.0073 0.0183 0.2107
Echinococcus granulosus neuropeptide receptor A26 0.0941 0.2793 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0016 0.0842
Echinococcus granulosus expressed conserved protein 0.0187 0.0527 0.1886
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0059 0.0059
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0029 0.0159
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0051 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0383 0.1915
Brugia malayi Doublecortin family protein 0.0019 0.0023 0.0104
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0115 0.0411
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.0595
Echinococcus granulosus lamin dm0 0.0055 0.0129 0.0461
Echinococcus granulosus dnaJ subfamily B 0.0411 0.12 0.4295
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.015 0.8025
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0059 0.072
Loa Loa (eye worm) beta-lactamase 0.0073 0.0183 0.087
Loa Loa (eye worm) DR-78 0.0015 0.0009 0.004
Echinococcus multilocularis nibrin 0.002 0.0024 0.0024
Brugia malayi Thioredoxin reductase 0.005 0.0114 0.0537
Brugia malayi nuclear hormone receptor 0.0031 0.0059 0.0277
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0065
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0059 0.0295
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0024 0.0489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0383 0.0383
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0183 0.2107
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0038 0.0274
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0343 0.2424
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.2001 0.2001
Brugia malayi dTDP-4-dehydrorhamnose 3,5-epimerase 0.0373956 1 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0014 0.0072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0305 0.2142
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0059 0.0277
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0183 0.2025
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.067 0.3186
Loa Loa (eye worm) hypothetical protein 0.0086 0.0221 0.1051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.006 0.03
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0009 0.0033
Giardia lamblia Replication factor C, subunit 1 0.002 0.0024 0.083
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0183 0.1242
Trichomonas vaginalis esterase, putative 0.0073 0.0183 0.2107
Toxoplasma gondii thioredoxin reductase 0.005 0.0114 0.6178
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0029 0.0133
Mycobacterium ulcerans dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD 0.0226 0.0642 0.7884
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0159 0.2516
Echinococcus multilocularis lamin dm0 0.0055 0.0129 0.0129
Brugia malayi MAP kinase sur-1 0.005 0.0115 0.0543
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0183 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0029 0.0094
Schistosoma mansoni hypothetical protein 0.0082 0.0212 0.106
Onchocerca volvulus 0.0055 0.0129 0.1581
Onchocerca volvulus 0.0073 0.0183 0.2257
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0029 0.0159
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0059 0.0059
Mycobacterium ulcerans beta-lactamase 0.0073 0.0183 0.2107
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0069 0.3747
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0009 0.004
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0159 0.0796
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0128 0.141
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.0403 0.2013
Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-rhamnose modification protein) (dTDP-rhamnose biosynthesis protein) (dTDP-rh 0.0226 0.0642 0.4646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0383 0.1372
Echinococcus multilocularis lamin 0.0055 0.0129 0.0129
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0115 0.5901
Echinococcus granulosus tar DNA binding protein 0.0066 0.0164 0.0588
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0029 0.0094
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0009 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0183 0.1242
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0038 0.2032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.015 0.1691
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0024 0.0746
Schistosoma mansoni pyruvate kinase 0.0035 0.0069 0.0346
Brugia malayi nuclear receptor RXR 0.0017 0.0014 0.0065
Mycobacterium leprae dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIP 0.0281 0.081 1
Brugia malayi hypothetical protein 0.0017 0.0014 0.0065
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0029 0.0753
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.015 0.0752
Echinococcus granulosus survival motor neuron protein 1 0.0711 0.2101 0.752
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0024 0.129
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0009 0.0009
Plasmodium falciparum glutathione reductase 0.005 0.0114 0.8864
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.0563 0.2016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0059 0.0059
Onchocerca volvulus 0.0019 0.0023 0.027
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0024 0.0489
Echinococcus multilocularis neuropeptide receptor A26 0.0941 0.2793 0.2793
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0024 0.044
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0059 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0059 0.0277
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0016 0.1208
Onchocerca volvulus 0.0073 0.0183 0.2257
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0029 0.0159
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0383 0.1821
Schistosoma mansoni intermediate filament proteins 0.0055 0.0129 0.0643
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0059 0.0277
Mycobacterium ulcerans lipase LipD 0.0073 0.0183 0.2107
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0059 0.0211
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0069 0.3747
Loa Loa (eye worm) hypothetical protein 0.0054 0.0128 0.0606
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0221 0.0793
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0115 0.1243
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0300186 0.643299 0.643299
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0029 0.0754
Schistosoma mansoni ap endonuclease 0.002 0.0024 0.0118
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Mycobacterium leprae dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-RHAMNOSE MODIFICATION PROTEIN) (dTDP-RHAMNOSE BIOSYNTHESIS PROTEIN) (dTDP-RH 0.0156 0.0434 0.5207
Brugia malayi hypothetical protein 0.0146 0.0403 0.1915
Schistosoma mansoni topbp1 0.002 0.0024 0.0122
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0183 0.2963
Toxoplasma gondii exonuclease III APE 0.002 0.0024 0.1245
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0038 0.2916
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0183 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0059 0.0277
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0029 0.0133
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0029 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0059 0.0295
Echinococcus multilocularis cpg binding protein 0.0031 0.0056 0.0056
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0029 0.0754
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0069 0.0668
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0183 1
Brugia malayi tailless protein 0.0015 0.0009 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0029 0.0094
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0029 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0119 0.0764
Brugia malayi hypothetical protein 0.0711 0.2101 1
Leishmania major hypothetical protein, conserved 0.0026 0.0044 0.1642
Loa Loa (eye worm) hypothetical protein 0.0128 0.0349 0.1659
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0044 0.2345
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0059 0.0277
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0059 0.0211
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0016 0.0842
Echinococcus granulosus intermediate filament protein 0.0055 0.0129 0.0461
Schistosoma mansoni hypothetical protein 0.0411 0.12 0.5994
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0183 0.2107
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0065
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0029 0.0097
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0024 0.1851
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0029 0.0094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0016 0.0073
Schistosoma mansoni lamin 0.0055 0.0129 0.0643
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0129 0.0609
Brugia malayi beta-lactamase family protein 0.0073 0.0183 0.087
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0077 0.0277
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0183 0.087
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0024 0.0103
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0183 0.1242
Echinococcus granulosus pyruvate kinase 0.0018 0.0018 0.0065
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0115 0.0543
Echinococcus multilocularis protein patched 0.0086 0.0221 0.0221
Chlamydia trachomatis DNA ligase 0.002 0.0024 0.0731
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0002 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0183 0.2107
Onchocerca volvulus Huntingtin homolog 0.0128 0.0349 0.4305
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Echinococcus multilocularis pyruvate kinase 0.0018 0.0018 0.0018
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0069 0.3172
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0183 0.1242
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0009 0.004
Schistosoma mansoni hypothetical protein 0.0082 0.0212 0.106
Echinococcus granulosus pyruvate kinase 0.0035 0.0069 0.0248
Onchocerca volvulus 0.002 0.0024 0.0291
Mycobacterium leprae dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIP 0.0373956 1 1
Brugia malayi hypothetical protein 0.0128 0.0349 0.1659
Leishmania major pyruvate kinase 0.0035 0.0069 0.3172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0383 0.1915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0383 0.1372
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0277
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0115 0.5901
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.1363 1
Onchocerca volvulus 0.0032 0.006 0.0733
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0183 1
Mycobacterium ulcerans hypothetical protein 0.0073 0.0183 0.2107
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0343 0.2424
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0009 0.004
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0069 0.0571
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0128 0.0831
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0069 0.0326
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0059 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0164 0.0821
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.087
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.062 0.2948
Loa Loa (eye worm) hypothetical protein 0.0128 0.0349 0.1659
Giardia lamblia Pyruvate kinase 0.0018 0.0018 0.021
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0044 0.0157
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0024 0.0103
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0029 0.0159
Brugia malayi hypothetical protein 0.0015 0.0009 0.004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0024 0.0108
Trichomonas vaginalis DTDP-4-dehydrorhamnose 3,5-epimerase, putative 0.0281 0.081 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0119 0.0764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0059 0.0277
Echinococcus multilocularis expressed conserved protein 0.0187 0.0527 0.0527
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0125 0.0341 0.4092
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0059 0.0211
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0038 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0183 0.1242
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0059 0.0277
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0159 0.057
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0069 0.3172
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0164 0.0779
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0029 0.0159
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.015 0.8191
Mycobacterium tuberculosis Conserved protein 0.0073 0.0183 0.1242
Brugia malayi nuclear receptor RXR 0.0015 0.0009 0.004
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0112
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0029 0.0094
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0159 0.8558
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0029 0.0133
Mycobacterium ulcerans dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC 0.0373956 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0065
Onchocerca volvulus 0.0021 0.0029 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0059 0.0277
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0024 0.0108
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0183 0.2025
Schistosoma mansoni rab6-interacting 0.0019 0.0023 0.0113
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0018 0.0956
Mycobacterium tuberculosis dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine dip 0.0281 0.081 0.5893
Brugia malayi conserved hypotetical protein 0.0015 0.0009 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0383 0.1821
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0115 0.1243
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0115 0.5901
Echinococcus multilocularis pyruvate kinase 0.0018 0.0018 0.0018
Brugia malayi CHE-14 protein 0.0086 0.0221 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.0373956 1 1
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0115 1
Schistosoma mansoni hypothetical protein 0.0145 0.04 0.2
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0038 0.0175
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.082 0.2936
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0183 0.1242
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0103
Onchocerca volvulus 0.0015 0.0009 0.0103
Onchocerca volvulus 0.0031 0.0059 0.072
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0029 0.0133
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.0403 0.0403
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0059 0.0295
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0226 0.0808
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0114 0.0114
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0069 0.0846
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0044 0.2345
Loa Loa (eye worm) oxidoreductase 0.0021 0.0029 0.0133
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0024 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0059 0.0059
Schistosoma mansoni lipoxygenase 0.0019 0.0023 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0059 0.0277
Echinococcus multilocularis survival motor neuron protein 1 0.0711 0.2101 0.2101
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0103
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0029 0.0754
Entamoeba histolytica hypothetical protein 0.0024 0.0038 0.0266
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.015 0.0539
Echinococcus multilocularis neuropeptide s receptor 0.0941 0.2793 0.2793
Schistosoma mansoni nuclear receptor 0.0015 0.0009 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0183 0.0917
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0277
Echinococcus multilocularis pyruvate kinase 0.0035 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0082 0.0212 0.106
Entamoeba histolytica hypothetical protein 0.0146 0.0403 0.7027
Echinococcus multilocularis pyruvate kinase 0.0018 0.0018 0.0018
Brugia malayi CXXC zinc finger family protein 0.0029 0.0051 0.024
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0023 0.0023
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0029 0.0133
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0044 0.3365
Onchocerca volvulus 0.0281 0.081 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0065
Echinococcus granulosus cpg binding protein 0.0031 0.0056 0.0201
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0009 0.0103

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 130 nM Antimalarial activity against erythrocyte stages of chloroquine-sensitive Plasmodium falciparum D10 infected in human erythrocytes by lactate dehydrogenase assay ChEMBL. 21875063
Ratio IC50 (functional) = 0.7 Resistance index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum K1 to IC50 for chloroquine-sensitive Plasmodium falciparum D10 ChEMBL. 21875063

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21875063

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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