Detailed view for TVAG_440230

Basic information

TDR Targets ID: 926400
Trichomonas vaginalis, synaptotagmin 1,2, putative
Source Database / ID: 

pI: 4.5843 | Length (AA): 1783 | MW (Da): 203983 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129223)

Species Accession Gene Product
Arabidopsis thaliana AT5G04220   synaptotagmin-3
Arabidopsis thaliana AT2G20990   synaptotagmin A
Arabidopsis thaliana AT1G20080   synaptotagmin-2
Brugia malayi Bm1_45140   Synaptotagmin I
Candida albicans CaO19.10521   similar to S. cerevisiae YML072C
Candida albicans CaO19.2353   similar to S. cerevisiae YOR086C
Candida albicans CaO19.9889   similar to S. cerevisiae YOR086C
Candida albicans CaO19.9398   match to pfam Ca2+-dependent membrane-targeting module
Candida albicans CaO19.3003   similar to S. cerevisiae YML072C
Candida albicans CaO19.1840   match to pfam Ca2+-dependent membrane-targeting module
Caenorhabditis elegans CELE_F42G9.7   Protein SNT-2
Homo sapiens ENSG00000139641   extended synaptotagmin-like protein 1
Loa Loa (eye worm) LOAG_00668   hypothetical protein
Mus musculus ENSMUSG00000025366   extended synaptotagmin-like protein 1
Oryza sativa 4329259   Os02g0448400
Oryza sativa 4347715   Os09g0538800
Oryza sativa 4327448   Os01g0819200
Saccharomyces cerevisiae YNL087W   Tcb2p
Saccharomyces cerevisiae YOR086C   Tcb1p
Saccharomyces cerevisiae YML072C   Tcb3p
Trichomonas vaginalis TVAG_260390   vab10 spectraplakin, putative
Trichomonas vaginalis TVAG_569860   synaptotagmin, putative
Trichomonas vaginalis TVAG_591330   synaptotagmin, putative
Trichomonas vaginalis TVAG_527560   synaptotagmin 1, 3, C.elegans, putative
Trichomonas vaginalis TVAG_485580   synaptotagmin 1,2, putative
Trichomonas vaginalis TVAG_440230   synaptotagmin 1,2, putative
Trichomonas vaginalis TVAG_527570   synaptotagmin, putative

Essentiality

TVAG_440230 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F42G9.7 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0107 0.5 0.5
0.0057 0.3491 0.5
0.0058 0.5 0.5
0.0121 1 1
0.0071 0.2549 0.5
0.0018 0.5 0.5
0.0125 0.3893 0.3893
0.005 0.2612 0.5
0.0109 0.4866 0.5
0.0072 0.2639 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_440230 (Trichomonas vaginalis), synaptotagmin 1,2, putative
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