pI: 10.6252 |
Length (AA): 196 |
MW (Da): 22373 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128929)
Species | Accession | Gene Product |
---|---|---|
Candida albicans | CaO19.3831 | Possible telomerase regulator or RNA-binding protein |
Candida albicans | CaO19.11312 | Possible telomerase regulator or RNA-binding protein |
Caenorhabditis elegans | CELE_T23G7.3 | Protein T23G7.3 |
Cryptosporidium hominis | Chro.50372 | hypothetical protein |
Cryptosporidium parvum | cgd5_240 | G patch domain containing protein |
Dictyostelium discoideum | DDB_G0276189 | hypothetical protein |
Dictyostelium discoideum | DDB_G0278987 | hypothetical protein |
Drosophila melanogaster | Dmel_CG11180 | CG11180 gene product from transcript CG11180-RB |
Echinococcus granulosus | EgrG_001009700 | D111 G patch |
Echinococcus multilocularis | EmuJ_000132700 | G patch domain containing protein 4 |
Leishmania braziliensis | LbrM.06.1000 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_061060.1 | G-patch domain containing protein, putative |
Leishmania infantum | LinJ.06.1060 | hypothetical protein, conserved |
Leishmania major | LmjF.06.1020 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.06.1020 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_11082 | hypothetical protein |
Mus musculus | ENSMUSG00000021958 | PIN2/TERF1 interacting, telomerase inhibitor 1 |
Oryza sativa | 4344309 | Os07g0682000 |
Plasmodium berghei | PBANKA_0937300 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_0908000 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_091165 | hypothetical protein, conserved |
Plasmodium yoelii | PY03703 | G-patch domain, putative |
Saccharomyces cerevisiae | YGR280C | Pxr1p |
Schistosoma japonicum | Sjp_0092550 | ko:K09270 transcription factor SOX7/8/9/10/18 (SOX group E/F), putative |
Schistosoma mansoni | Smp_010140.3 | hypothetical protein |
Schistosoma mansoni | Smp_010140.2 | hypothetical protein |
Trypanosoma brucei gambiense | Tbg972.7.6540 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.5640 | G-patch domain containing protein, putative |
Trypanosoma congolense | TcIL3000_7_4610 | G-patch domain containing protein, putative |
Trypanosoma cruzi | TcCLB.507559.40 | G-patch domain containing protein, putative |
Trypanosoma cruzi | TcCLB.510303.90 | G-patch domain containing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.5640 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.5640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.5640 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.5640 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
YGR280C | Saccharomyces cerevisiae | inviable | yeastgenome |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.