Detailed view for LOAG_08927

Basic information

TDR Targets ID: 939035
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.2382 | Length (AA): 131 | MW (Da): 15582 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05821   NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008137   NADH dehydrogenase (ubiquinone) activity  
GO:0005739   mitochondrion  
GO:0003954   NADH dehydrogenase activity  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 103 4fmv (A) 70 161 16.00 0.62 0.02 0.840923 -0.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133612)

Species Accession Gene Product
Brugia malayi Bm1_44000   NADH-ubiquinone oxidoreductase ASHI subunit, mitochondrial precursor
Caenorhabditis elegans CELE_Y51H1A.3   Protein Y51H1A.3, isoform B
Drosophila melanogaster Dmel_CG3192   CG3192 gene product from transcript CG3192-RA
Echinococcus granulosus EgrG_000085900   NADH dehydrogenase ubiquinone 1 beta
Echinococcus multilocularis EmuJ_000085900   NADH dehydrogenase (ubiquinone) 1 beta
Homo sapiens ENSG00000166136   NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
Loa Loa (eye worm) LOAG_08927   hypothetical protein
Mus musculus ENSMUSG00000025204   NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8
Onchocerca volvulus OVOC10684  
Schistosoma japonicum Sjp_0060080   ko:K03964 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8, putative
Schistosoma mansoni Smp_036400.1   NADH-ubiquinone oxidoreductase
Schistosoma mansoni Smp_036400.2   NADH-ubiquinone oxidoreductase
Schmidtea mediterranea mk4.000416.06   Putative nadh-ubiquinone oxidoreductase ashi subunit

Essentiality

LOAG_08927 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y51H1A.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y51H1A.3 Caenorhabditis elegans slow growth wormbase
CELE_Y51H1A.3 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0282 0.2898 0.6793
0.0243 0.2898 0.6793
0.0238 0.2898 0.6793
0.0487 0.292 0.7017
0.0487 0.3106 0.7105
0.0483 0.3592 0.6963
0.0487 0.292 0.7017
0.0498 0.3081 0.6632
0.0497 0.2984 0.6886
0.0282 0.3364 0.6749
0.0236 0.2872 0.6765
0.0509 0.3107 0.7009
0.0479 0.2893 0.6879
0.0236 0.2872 0.6765
0.0494 0.3547 0.6053
0.0477 0.2787 0.6879
0.0478 0.3576 0.5979
0.0243 0.2898 0.6793
0.0503 0.3047 0.6623
0.0472 0.3548 0.6926
0.0228 0.2971 0.6858
0.0238 0.2898 0.6793
0.0505 0.3535 0.6133
0.0474 0.3833 0.5432
0.0484 0.3584 0.6425
0.0527 0.3146 0.7021
0.0477 0.3558 0.6935
0.047 0.3533 0.6102
0.0515 0.3086 0.6973
0.0474 0.3833 0.5432

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08927 (Loa Loa (eye worm)), hypothetical protein
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