Detailed view for LOAG_03067

Basic information

TDR Targets ID: 940488
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 8.6926 | Length (AA): 181 | MW (Da): 20789 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01146   Caveolin

Gene Ontology

Mouse over links to read term descriptions.
GO:0070836   GO:caveola assembly  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136611)

Species Accession Gene Product
Brugia malayi Bm1_36280   Caveolin-1
Caenorhabditis elegans CELE_T13F2.8   Protein CAV-1, isoform B
Homo sapiens ENSG00000105974   caveolin 1, caveolae protein, 22kDa
Loa Loa (eye worm) LOAG_03067   hypothetical protein
Mus musculus ENSMUSG00000007655   caveolin 1, caveolae protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens caveolin 1, caveolae protein, 22kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0542 0.2932 0.2932
0.0680457 0.36637 0.517912
0.0513 1 1
0.0542 0.2932 0.2932
0.0517 0.3864 0.3864
0.0507 0.5787 0.5787
0.0509 0.3671 0.3588
0.0558 0.2764 0.2764
0.0515 0.3779 0.3779
0.0526 0.5531 0.7483
0.0534 0.345 1
0.0559 0.2757 0.2757
0.054 0.4248 0.4248
0.0558 0.2647 0.2646
0.0542 0.2932 0.2932
0.0538 0.5052 0.5052
0.0529 0.2518 0.2518
0.0558 0.2647 0.2646
0.0507 0.4369 0.4282
0.0508 1 1
0.0522 0.4848 0.4753
0.0516 0.5542 0.5457
0.0542 0.2932 0.2932
0.0519 1 1
0.0525 0.324 0.3094
0.0542 0.2932 0.2932
0.0517 0.613 0.613

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_03067 (Loa Loa (eye worm)), hypothetical protein
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