Detailed view for LOAG_11406

Basic information

TDR Targets ID: 941175
Loa Loa (eye worm), developmentally regulated GTP-binding protein 1
Source Database / ID:  KEGG  

pI: 8.0433 | Length (AA): 313 | MW (Da): 35379 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01926   50S ribosome-binding GTPase
PF02824   TGS domain
PF16897   C-terminal region of MMR_HSR1 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 304 4a9a (A) 65 369 59.00 0 1 1.69755 -0.67
221 304 2eki (A) 4 87 64.00 0 1 1.01477 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127528)

Species Accession Gene Product
Arabidopsis thaliana AT4G39520   developmentally regulated G-protein
Babesia bovis BBOV_IV004700   developmentally regulated GTP-binding protein 1, putative
Brugia malayi Bm1_45105   Developmentally regulated GTP-binding protein 1, putative
Candida albicans CaO19.12549   predicted GTPase similar to S. cerevisiae FUN11 (YAL036C)
Candida albicans CaO19.5083   predicted GTPase similar to S. cerevisiae FUN11 (YAL036C)
Caenorhabditis elegans CELE_T28D6.6   Protein T28D6.6, isoform A
Caenorhabditis elegans CELE_T28D6.6a   Protein T28D6.6, isoform B
Cryptosporidium hominis Chro.30404   GTP-binding-like protein
Cryptosporidium parvum cgd3_3580   DRG-like OBG family GTpase fused to an RNA binding domain TGS domain, Fun11p
Dictyostelium discoideum DDB_G0289317   hypothetical protein
Drosophila melanogaster Dmel_CG8340   upstream of RpIII128
Echinococcus granulosus EgrG_000250600   developmentally regulated gtp binding protein 1
Entamoeba histolytica EHI_058460   GTP-binding protein, putative
Echinococcus multilocularis EmuJ_000250600   developmentally regulated gtp binding protein 1
Giardia lamblia GL50803_16200   Developmentally regulated GTP-binding protein 1
Homo sapiens ENSG00000185721   developmentally regulated GTP binding protein 1
Leishmania braziliensis LbrM.35.2490   developmentally regulated GTP-binding protein 1, putative
Leishmania donovani LdBPK_362380.1   developmentally regulated GTP-binding protein 1, putative
Leishmania infantum LinJ.36.2380   developmentally regulated GTP-binding protein 1, putative
Leishmania major LmjF.36.2250   developmentally regulated GTP-binding protein 1, putative
Leishmania mexicana LmxM.36.2250   developmentally regulated GTP-binding protein 1, putative
Loa Loa (eye worm) LOAG_11406   developmentally regulated GTP-binding protein 1
Loa Loa (eye worm) LOAG_01268   developmentally regulated GTP binding protein 1
Mus musculus ENSMUSG00000020457   developmentally regulated GTP binding protein 1
Neospora caninum NCLIV_018880   GTP-binding protein 1, related
Oryza sativa 4343980   Os07g0627800
Plasmodium berghei PBANKA_1239200   ribosome-interacting GTPase 1, putative
Plasmodium falciparum PF3D7_0524400   ribosome-interacting GTPase 1, putative
Plasmodium knowlesi PKNH_1008500   ribosome-interacting GTPase 1, putative
Plasmodium vivax PVX_196290   unspecified product
Plasmodium vivax PVX_222290   unspecified product
Plasmodium vivax PVX_080030   developmentally regulated GTP-binding protein 1, putative
Plasmodium yoelii PY06396   GTP-binding-like protein
Saccharomyces cerevisiae YAL036C   Rbg1p
Schistosoma japonicum Sjp_0052790   ko:K06944 similar to developmentally regulated GTP binding protein 1, putative
Schistosoma mansoni Smp_173180.1   developmentally regulated GTP-binding protein 1 (drg 1)
Schistosoma mansoni Smp_173180.2   developmentally regulated GTP-binding protein 1 (drg 1)
Schmidtea mediterranea mk4.001187.03   Developmentally-regulated GTP-binding protein 1
Trypanosoma brucei gambiense Tbg972.10.8300   developmentally regulated GTP-binding protein, putative
Trypanosoma brucei Tb927.10.6800   developmentally regulated GTP-binding protein, putative
Trypanosoma cruzi TcCLB.510187.160   developmentally regulated GTP-binding protein, putative
Toxoplasma gondii TGME49_244310   GTP-binding protein
Theileria parva TP01_0279   developmentally regulated GTP-binding protein 1, putative
Trichomonas vaginalis TVAG_327110   GTP-binding protein, putative

Essentiality

LOAG_11406 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.6800 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.6800 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.6800 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.6800 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T28D6.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_T28D6.6 Caenorhabditis elegans larval arrest wormbase
CELE_T28D6.6 Caenorhabditis elegans larval lethal wormbase
CELE_T28D6.6 Caenorhabditis elegans sterile wormbase
TGME49_244310 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_11406 (Loa Loa (eye worm)), developmentally regulated GTP-binding protein 1
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