Detailed view for LOAG_11661

Basic information

TDR Targets ID: 941528
Loa Loa (eye worm), protein kinase C and casein kinase substrate in neurons protein 2
Source Database / ID:  KEGG  

pI: 7.1083 | Length (AA): 477 | MW (Da): 54374 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018   SH3 domain
PF00611   Fes/CIP4, and EFC/F-BAR homology domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 287 3i2w (B) 14 297 31.00 0 1 1.00539 -0.37
6 295 3i2w (A) 16 302 35.00 0 1 0.836166 0.28
6 297 2x3v (A) 15 304 30.00 0 1 0.995459 -0.13
9 143 3qwe (A) 90 224 15.00 0.35 0.11 0.477019 -0.7
403 460 1g2b (A) 0 44 22.00 0 0.18 0.266793 -0.6
407 477 1x2q (A) 4 72 36.00 0 1 0.557047 -0.77
415 475 1oeb (A) 0 54 36.00 0 1 0.541083 -1.05
423 475 2a28 (A) 2 54 38.00 0 1 0.584311 -0.93
425 471 6gbu (E) 7 55 49.00 0.65 1 0.481833 -0.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131319)

Species Accession Gene Product
Brugia malayi Bm1_10320   Protein kinase C and casein kinase substrate in neurons protein 2
Caenorhabditis elegans CELE_F45E1.7   Protein SDPN-1, isoform A
Drosophila melanogaster Dmel_CG33094   Syndapin
Echinococcus granulosus EgrG_001090800   protein kinase C and casein kinase substrate in
Echinococcus multilocularis EmuJ_001090800   protein kinase C and casein kinase substrate in
Homo sapiens ENSG00000100266   protein kinase C and casein kinase substrate in neurons 2
Homo sapiens ENSG00000124507   protein kinase C and casein kinase substrate in neurons 1
Loa Loa (eye worm) LOAG_11661   protein kinase C and casein kinase substrate in neurons protein 2
Mus musculus ENSMUSG00000040276   protein kinase C and casein kinase substrate in neurons 1
Mus musculus ENSMUSG00000016664   protein kinase C and casein kinase substrate in neurons 2
Schistosoma japonicum Sjp_0030470   Protein kinase C and casein kinase substrate in neurons protein 2, putative
Schistosoma mansoni Smp_140490   membrane traffic protein
Schmidtea mediterranea mk4.023141.00  
Schmidtea mediterranea mk4.012343.00  
Schmidtea mediterranea mk4.009944.00  
Schmidtea mediterranea mk4.012207.00  
Schmidtea mediterranea mk4.007671.00  
Schmidtea mediterranea mk4.023525.02  
Schmidtea mediterranea mk4.003665.00  
Schmidtea mediterranea mk4.016565.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0027 0.3179 0.3179
0.0027 0.3179 0.3179
0.0064 0.3347 0.3362
0.0029 0.4037 0.4037
0.0336199 0.276589 0.265254
0.0048 0.281 0.281
0.0075 0.2576 0.2576
0.0059 0.3 0.3006
0.0048 0.3625 0.3625
0.0065 0.3464 0.32
0.0378 0.315 0.3101
0.0351989 0.270507 0.26116
0.0137 0.2846 0.2741
0.00394418 0.278418 0.262031
0.0039 0.2713 0.2713
0.0039 0.2713 0.2713
0.0322685 0.273741 0.262341
0.0029 0.4037 0.4037
0.0061 1 1
0.0282 0.283 0.4202
0.0068 0.2794 0.2794
0.0282 0.283 0.4202
0.0137 0.3036 0.3036
0.00394418 0.278418 0.262031
0.0065 0.3464 0.32

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_11661 (Loa Loa (eye worm)), protein kinase C and casein kinase substrate in neurons protein 2
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