Detailed view for LOAG_12889

Basic information

TDR Targets ID: 941986
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 7.3287 | Length (AA): 316 | MW (Da): 35732 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF10540   Munc13 (mammalian uncoordinated) homology domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0019992   diacylglycerol binding  
GO:0007268   synaptic transmission  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 124 5uf7 (A) 1390 1480 62.00 0 0.98 0.662205 0.84
1 115 3swh (A) 1390 1514 61.00 0.000000025 1 0.398224 0.74
20 117 5ue8 (A) 1355 1516 43.00 0.000087 1 0.878427 -0.7
29 118 5ue8 (A) 1363 1517 44.00 0 0.83 0.85591 -0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129715)

Species Accession Gene Product
Brugia malayi Bm1_11345   hypothetical protein
Caenorhabditis elegans CELE_ZK524.2   Protein UNC-13, isoform F
Drosophila melanogaster Dmel_CG2999   CG2999 gene product from transcript CG2999-RD
Echinococcus granulosus EgrG_001081150   C2 calcium dependent membrane targeting
Echinococcus granulosus EgrG_001103400   unc 13 munc13
Echinococcus granulosus EgrG_000344100   isocitrate dehydrogenase NAD subunit
Echinococcus multilocularis EmuJ_001081150   C2 calcium dependent membrane targeting
Echinococcus multilocularis EmuJ_000019800   protein unc 13 B
Echinococcus multilocularis EmuJ_000344100   isocitrate dehydrogenase (NAD) subunit
Echinococcus multilocularis EmuJ_000020700   unc 13 (munc13)
Echinococcus multilocularis EmuJ_001103400   unc 13 (munc13)
Homo sapiens ENSG00000130477   unc-13 homolog A (C. elegans)
Homo sapiens ENSG00000198722   unc-13 homolog B (C. elegans)
Homo sapiens 440279   unc-13 homolog C (C. elegans)
Loa Loa (eye worm) LOAG_09270   hypothetical protein
Loa Loa (eye worm) LOAG_12889   hypothetical protein
Loa Loa (eye worm) LOAG_07233   hypothetical protein
Mus musculus ENSMUSG00000028456   unc-13 homolog B (C. elegans)
Mus musculus 382018   unc-13 homolog A (C. elegans)
Mus musculus ENSMUSG00000062151   unc-13 homolog C (C. elegans)
Schistosoma japonicum Sjp_0013060   Protein unc-13 homolog A, putative
Schistosoma japonicum Sjp_0121840   IPR008973,C2 calcium/lipid-binding region, CaLB,domain-containing
Schistosoma japonicum Sjp_0013080   hypothetical protein
Schistosoma japonicum Sjp_0121670   expressed protein
Schistosoma japonicum Sjp_0013050   ko:K00030 isocitrate dehydrogenase (NAD+) [EC1.1.1.41], putative
Schistosoma japonicum Sjp_0013070   Protein unc-13 homolog B, putative
Schistosoma japonicum Sjp_0041290   Protein unc-13 homolog B, putative
Schistosoma japonicum Sjp_0107980   Protein unc-13 homolog C, putative
Schistosoma mansoni Smp_134590   unc-13 (munc13)
Schistosoma mansoni Smp_172040   unc-13 (munc13)
Schmidtea mediterranea mk4.001033.11   Putative unc-13
Schmidtea mediterranea mk4.007590.00   Putative unc-13
Schmidtea mediterranea mk4.000347.22   Putative unc-13
Schmidtea mediterranea mk4.000347.21  
Schmidtea mediterranea mk4.000347.19  
Schmidtea mediterranea mk4.001033.08  
Schmidtea mediterranea mk4.006929.00   Putative unc-13
Schmidtea mediterranea mk4.007590.01   Putative unc-13
Schmidtea mediterranea mk4.000347.24   Phorbol ester/diacylglycerol-binding protein unc-13
Schmidtea mediterranea mk4.004047.00   Putative unc-13
Schmidtea mediterranea mk4.001033.10   Putative unc-13

Essentiality

LOAG_12889 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK524.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0071 0.2549 1
0.0018 0.5 0.5
0.0107 0.5 0.5
0.0125 0.3893 0.3893
0.0109 0.4866 1
0.0058 0.5 0.5
0.005 0.2612 0.9039
0.0072 0.2639 0.9142
0.0057 0.3491 0.3491
0.0121 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_12889 (Loa Loa (eye worm)), hypothetical protein
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