Detailed view for LOAG_04191

Basic information

TDR Targets ID: 943827
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.3552 | Length (AA): 295 | MW (Da): 33749 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02338   OTU-like cysteine protease

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 136 4uos (A) 22 152 14.00 0 0.28 0.690127 -1.35
12 135 5cwo (A) 51 173 16.00 0 0.19 0.693739 -1.42
17 69 5wsu (C) 786 835 44.00 0.096 0.12 0.630061 -0.64
104 283 3tmp (A) 173 340 27.00 0 1 0.72567 0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128771)

Species Accession Gene Product
Arabidopsis thaliana AT3G62940   cysteine proteinases family protein
Babesia bovis BBOV_III011220   hypothetical protein
Brugia malayi Bm1_02270   OTU-like cysteine protease family protein
Candida albicans CaO19.1959   similar to S. cerevisiae YHL013C
Candida albicans CaO19.9514   similar to S. cerevisiae YHL013C
Caenorhabditis elegans CELE_F21D5.2   Protein OTUB-3, isoform C
Cryptosporidium hominis Chro.40502   hypothetical protein
Cryptosporidium parvum cgd4_4430   OTU like cysteine protease
Dictyostelium discoideum DDB_G0279375   OTU domain containin protein
Drosophila melanogaster Dmel_CG7857   CG7857 gene product from transcript CG7857-RA
Echinococcus granulosus EgrG_000728500   OTU domain containing protein 6B
Echinococcus multilocularis EmuJ_000728500   OTU domain containing protein 6B
Homo sapiens ENSG00000155100   OTU domain containing 6B
Loa Loa (eye worm) LOAG_04191   hypothetical protein
Mus musculus ENSMUSG00000040550   OTU domain containing 6B
Neospora caninum NCLIV_018240   Similar to uniprot
Oryza sativa 4337022   Os04g0619500
Plasmodium berghei PBANKA_0907300   OTU domain-containing protein, putative
Plasmodium falciparum PF3D7_1141700   OTU domain-containing protein, putative
Plasmodium knowlesi PKNH_0939500   OTU domain-containing protein, putative
Plasmodium vivax PVX_092690   hypothetical protein, conserved
Plasmodium yoelii PY03414   hypothetical protein
Saccharomyces cerevisiae YHL013C   Otu2p
Schistosoma japonicum Sjp_0012110   OTU domain-containing protein 2, putative
Schistosoma mansoni Smp_030280.2   C64 protease (C64 family)
Schmidtea mediterranea mk4.000046.08  
Toxoplasma gondii TGME49_243510   OTU family cysteine protease
Theileria parva TP02_0742   hypothetical protein
Trichomonas vaginalis TVAG_101350   OTU domain-containing protein 6B, putative

Essentiality

LOAG_04191 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_243510 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_04191 (Loa Loa (eye worm)), hypothetical protein
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