Detailed view for LOAG_06428

Basic information

TDR Targets ID: 945576
Loa Loa (eye worm), phosphatidylinositol 3-kinase catalytic subunit gamma
Source Database / ID:  KEGG  

pI: 9.0049 | Length (AA): 431 | MW (Da): 49631 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF00787   PX domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016301   kinase activity  
GO:0035091   phosphoinositide binding  
GO:0048015   phosphoinositide-mediated signaling  
GO:0046854   phosphoinositide phosphorylation  

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 121 2y3a (A) 936 1057 27.00 0.00000000052 0.95 0.600742 0.18
2 75 1he8 (A) 958 1051 32.00 0.033 0.28 0.369794 1.07
3 113 4uwh (A) 761 872 30.00 0 0.87 0.573141 0.06
153 264 2wwe (A) 0 1303 28.00 0 0.93 0.659461 -1.23
292 431 1v27 (A) 3 136 25.00 0 1 0.600426 -0.21
297 400 4ldc (A) 268 370 43.00 0.00000000047 1 0.715299 -0.41
297 398 1dqv (A) 431 531 34.00 0.00015 0.96 0.586659 0.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130562)

Species Accession Gene Product
Brugia malayi Bm1_05655   Phosphatidylinositol 3- and 4-kinase family protein
Caenorhabditis elegans CELE_F39B1.1   Protein PIKI-1
Drosophila melanogaster Dmel_CG11621   Phosphotidylinositol 3 kinase 68D
Echinococcus granulosus EgrG_001094200   phosphatidylinositol 4 phosphate 3 kinase C2
Entamoeba histolytica EHI_040690   phosphatidylinositol 3-kinase, putative
Echinococcus multilocularis EmuJ_001094200   phosphatidylinositol 4 phosphate 3 kinase C2
Homo sapiens ENSG00000133056   phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Homo sapiens ENSG00000011405   phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Homo sapiens ENSG00000139144   phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Loa Loa (eye worm) LOAG_05835   hypothetical protein
Loa Loa (eye worm) LOAG_06428   phosphatidylinositol 3-kinase catalytic subunit gamma
Mus musculus ENSMUSG00000030660   phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
Mus musculus ENSMUSG00000026447   phosphoinositide-3-kinase, class 2, beta polypeptide
Mus musculus ENSMUSG00000030228   phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
Schistosoma japonicum Sjp_0207840   expressed protein
Schistosoma japonicum Sjp_0100430   Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, putative
Schistosoma japonicum Sjp_0311580   expressed protein
Schistosoma japonicum Sjp_0100820   Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, putative
Schistosoma mansoni Smp_172400   phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K
Schmidtea mediterranea mk4.001675.00   Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PI3K
Schmidtea mediterranea mk4.001675.02  
Schmidtea mediterranea mk4.001675.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta Compounds References
Homo sapiens phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Compounds References
Homo sapiens phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0052 0.3407 0.2917
0.0071 0.2549 1
0.0103 0.4036 0.4141
0.0058 0.5 0.5
0.0049 0.3565 0.3565
0.0121 1 1
0.0058 0.2892 0.2983
0.0103 0.3407 0.2983
0.0103 0.4036 0.4141
0.0109 0.4866 1
0.0099 0.3407 0.2983
0.0058 0.2892 0.2983
0.0107 0.5 0.5
0.0096 0.3407 0.2983
0.0058 0.2892 0.2983
0.005 0.2612 0.9039
0.0125 0.3893 0.3893
0.0018 0.5 0.5
0.0053 0.3407 0.292
0.0057 0.3491 0.3491
0.0049 0.3565 0.3565
0.0072 0.2639 0.9142

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_06428 (Loa Loa (eye worm)), phosphatidylinositol 3-kinase catalytic subunit gamma
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