pI: 4.8609 |
Length (AA): 211 |
MW (Da): 24324 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 202 | 1att (A) | 186 | 405 | 36.00 | 0 | 0.89 | 1.14585 | 0.78 |
2 | 193 | 1att (A) | 187 | 394 | 38.00 | 0 | 0.87 | 1.10725 | 0.84 |
2 | 164 | 4ga7 (A) | 132 | 325 | 36.00 | 0 | 0.98 | 0.876812 | 1.48 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126693)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G62170 | putative non-inhibitory serpin-Z5 |
Arabidopsis thaliana | AT2G26390 | serpin-Z3 |
Arabidopsis thaliana | AT3G45220 | serpin-Z4 |
Arabidopsis thaliana | AT1G47710 | serpin-ZX |
Arabidopsis thaliana | AT2G14540 | serpin-2 |
Arabidopsis thaliana | AT1G64030 | serpin 3 |
Arabidopsis thaliana | AT2G25240 | serpin CCP3 |
Brugia malayi | Bm1_25935 | serpin |
Brugia malayi | Bm1_03995 | serpin (BmSERPIN) |
Brugia malayi | Bm1_25940 | serpin |
Brugia malayi | Bm1_04960 | serpin (BmSERPIN) |
Brugia malayi | Bm1_25950 | hypothetical protein |
Brugia malayi | Bm1_25930 | hypothetical protein |
Brugia malayi | Bm1_25955 | serpin |
Brugia malayi | Bm1_09430 | BmSERPIN |
Brugia malayi | Bm1_25945 | serpin |
Brugia malayi | Bm1_09775 | serpin |
Brugia malayi | Bm1_18355 | serpin |
Caenorhabditis elegans | CELE_F20D6.4 | Protein SRP-7, isoform A |
Caenorhabditis elegans | CELE_C05E4.1 | Protein SRP-2 |
Caenorhabditis elegans | CELE_C03G6.19 | Protein SRP-6 |
Drosophila melanogaster | Dmel_CG33121 | Serpin 28Db |
Drosophila melanogaster | Dmel_CG9460 | Serpin 42De |
Drosophila melanogaster | Dmel_CG9334 | Serpin 38F |
Drosophila melanogaster | Dmel_CG18525 | Serpin 88Ea |
Drosophila melanogaster | Dmel_CG6717 | Serpin 28B |
Drosophila melanogaster | Dmel_CG31902 | Serpin 28Da |
Drosophila melanogaster | Dmel_CG8137 | Serpin 28F |
Drosophila melanogaster | Dmel_CG6687 | Serpin 88Eb |
Drosophila melanogaster | Dmel_CG9453 | Serpin 42Da |
Drosophila melanogaster | Dmel_CG9456 | Serpin 42Dd |
Drosophila melanogaster | Dmel_CG10913 | Serpin 55B |
Drosophila melanogaster | Dmel_CG12172 | Serpin 43Aa |
Echinococcus granulosus | EgrG_001193200 | serine protease inhibitor |
Echinococcus granulosus | EgrG_002066800 | serine protease inhibitor |
Echinococcus granulosus | EgrG_000824100 | Estrogen regulated protein EP45 |
Echinococcus granulosus | EgrG_001193100 | serine protease inhibitor |
Entamoeba histolytica | EHI_119330 | serine protease inhibitor, putative |
Echinococcus multilocularis | EmuJ_001193200 | serine protease inhibitor |
Echinococcus multilocularis | EmuJ_001193100 | serine protease inhibitor |
Giardia lamblia | GL50803_4653 | Serpin 1 |
Homo sapiens | ENSG00000163536 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
Homo sapiens | ENSG00000057149 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 |
Homo sapiens | ENSG00000021355 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
Homo sapiens | ENSG00000124570 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 |
Homo sapiens | ENSG00000206073 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 |
Loa Loa (eye worm) | LOAG_12154 | serpin |
Loa Loa (eye worm) | LOAG_15240 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13681 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11934 | serpin |
Loa Loa (eye worm) | LOAG_15773 | serpin |
Loa Loa (eye worm) | LOAG_12205 | serpin |
Mus musculus | ENSMUSG00000073602 | serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B |
Mus musculus | ENSMUSG00000073601 | serine (or cysteine) peptidase inhibitor, clade B, member 3C |
Mus musculus | ENSMUSG00000051029 | serine (or cysteine) peptidase inhibitor, clade B, member 1b |
Mus musculus | ENSMUSG00000044734 | serine (or cysteine) peptidase inhibitor, clade B, member 1a |
Mus musculus | ENSMUSG00000042842 | serine (or cysteine) peptidase inhibitor, clade B, member 6b |
Mus musculus | 666414 | predicted gene 8089 |
Mus musculus | 20713 | serine (or cysteine) peptidase inhibitor, clade I, member 1 |
Mus musculus | ENSMUSG00000044594 | serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A |
Mus musculus | 380839 | serine (or cysteine) peptidase inhibitor, clade B, member 1c |
Mus musculus | ENSMUSG00000060147 | serine (or cysteine) peptidase inhibitor, clade B, member 6a |
Mus musculus | ENSMUSG00000021404 | serine (or cysteine) peptidase inhibitor, clade B, member 9c |
Mus musculus | ENSMUSG00000058017 | serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D |
Neospora caninum | NCLIV_063150 | Serpin peptidase inhibitor, clade B (Ovalbumin), member 1, like 3, related |
Neospora caninum | NCLIV_062190 | GK22245, related |
Oryza sativa | 4326898 | Os01g0765400 |
Oryza sativa | 9269441 | Os11g0290600 |
Oryza sativa | 9270857 | Os03g0610650 |
Oryza sativa | 9268573 | Os11g0230400 |
Oryza sativa | 4333434 | Os03g0610800 |
Oryza sativa | 9267274 | Os11g0580100 |
Oryza sativa | 4324380 | Os01g0267300 |
Onchocerca volvulus | OVOC1850 |
|
Onchocerca volvulus | OVOC2080 |
|
Onchocerca volvulus | OVOC8529 |
|
Onchocerca volvulus | OVOC1983 |
|
Schistosoma japonicum | Sjp_0076600 | Serpin B9, putative |
Schistosoma japonicum | Sjp_0218430 | Serpin B9, putative |
Schistosoma mansoni | Smp_155560 | serine protease inhibitors serpins |
Schistosoma mansoni | Smp_062120 | serine protease inhibitors serpins |
Schistosoma mansoni | Smp_155550 | serine protease inhibitors serpins |
Schistosoma mansoni | Smp_155530 | serine protease inhibitors serpins |
Schistosoma mansoni | Smp_062080 | serine protease inhibitors serpins |
Schmidtea mediterranea | mk4.001637.04 | Minor histocompatibility protein HMSD variant form |
Schmidtea mediterranea | mk4.008095.01 | |
Schmidtea mediterranea | mk4.008267.00 | Minor histocompatibility protein HMSD variant form |
Schmidtea mediterranea | mk4.004115.01 | Minor histocompatibility protein HMSD variant form |
Schmidtea mediterranea | mk4.009226.00 | |
Schmidtea mediterranea | mk4.008630.01 | |
Schmidtea mediterranea | mk4.013569.01 | |
Schmidtea mediterranea | mk4.020562.00 | |
Schmidtea mediterranea | mk4.032367.00 | |
Schmidtea mediterranea | mk4.020562.01 | Minor histocompatibility protein HMSD variant form |
Toxoplasma gondii | TGME49_217430 | protease inhibitor PI1 |
Toxoplasma gondii | TGME49_246130 | serpin (serine proteinase inhibitor) superfamily protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_217430 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_246130 | Toxoplasma gondii | Probably non-essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.