Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | protease inhibitor PI1 | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | serine protease inhibitors serpins | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Echinococcus multilocularis | serine protease inhibitor | 0.0007 | 0.5 | 0.5 |
Toxoplasma gondii | serpin (serine proteinase inhibitor) superfamily protein | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | serpin | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin (BmSERPIN) | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin precursor | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Echinococcus multilocularis | Estrogen regulated protein EP45 | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | serine protease inhibitors serpins | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | Estrogen regulated protein EP45 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin (BmSERPIN) | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | serine protease inhibitors serpins | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | serine protease inhibitor | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Echinococcus multilocularis | serine protease inhibitor | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Giardia lamblia | Serpin 1 | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | serpin | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | serine protease inhibitors serpins | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | serine protease inhibitor | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | serpin | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | serpin | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Brugia malayi | Serpin protein 6 | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | serine protease inhibitors serpins | 0.0007 | 0.5 | 0.5 |
Brugia malayi | BmSERPIN | 0.0007 | 0.5 | 0.5 |
Entamoeba histolytica | serine protease inhibitor, putative | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | serpin protein 6 | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Brugia malayi | BmSERPIN, truncated | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | serpin | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | Estrogen regulated protein EP45 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | Estrogen regulated protein EP45 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | serpin | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | serine protease inhibitors serpins | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | serpin | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | plasminogen activator inhibitor 2 | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | serine protease inhibitor | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Max dose (functional) | = 200 mg kg-1 | Maximum tolerated (nonfatal) intraperitoneal dose tested in mice infected with Trypanosoma brucei. | ChEMBL. | 7097719 |
Max dose (functional) | = 200 mg kg-1 | Maximum tolerated (nonfatal) intraperitoneal dose tested in mice infected with Trypanosoma brucei. | ChEMBL. | 7097719 |
Min lytic concentration (functional) | = 20 uM | Minimum concentration producing complete lysis of all trypanosomes within 30 min at 37 degrees C in vitro | ChEMBL. | 7097719 |
Min lytic concentration (functional) | = 20 uM | Minimum concentration producing complete lysis of all trypanosomes within 30 min at 37 degrees C in vitro | ChEMBL. | 7097719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.