Detailed view for LOAG_11666

Basic information

TDR Targets ID: 947805
Loa Loa (eye worm), PRP38 family protein
Source Database / ID:  KEGG  

pI: 10.2788 | Length (AA): 361 | MW (Da): 42147 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03371   PRP38 family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
37 230 4rz9 (A) 1 174 19.00 0 1 0.727096 -0.78
47 249 5f5t (A) 24 211 20.00 0 0.99 0.759027 -0.76
95 155 5ms4 (A) 25 79 42.00 0.82 0.07 0.314875 1.25
225 317 5szg (B) 1854 1954 13.00 0 0.01 0.598318 -2.93
256 317 5wst (A) 865 926 16.00 0 0 0.754445 -4.61
257 331 5hmo (A) 813 881 29.00 0.023 0.02 0.752656 -3.39
293 357 2cot (A) 5 75 42.00 0.35 0.09 0.369955 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130216)

Species Accession Gene Product
Babesia bovis BBOV_III008900   PRP38 family protein
Brugia malayi Bm1_20635   PRP38 family protein
Caenorhabditis elegans CELE_Y108G3AL.2   Protein Y108G3AL.2
Dictyostelium discoideum DDB_G0288401   pre-mRNA processing factor 38
Drosophila melanogaster Dmel_CG1622   CG1622 gene product from transcript CG1622-RC
Escherichia coli b4487   putative periplasmic protein
Echinococcus granulosus EgrG_000216600   pre mRNA splicing factor 38B
Entamoeba histolytica EHI_083650   hypothetical protein
Echinococcus multilocularis EmuJ_000216600   pre mRNA splicing factor 38B
Homo sapiens ENSG00000134186   pre-mRNA processing factor 38B
Loa Loa (eye worm) LOAG_11666   PRP38 family protein
Mus musculus ENSMUSG00000027881   PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
Neospora caninum NCLIV_014960   hypothetical protein
Oryza sativa 4337972   Os05g0178900
Plasmodium berghei PBANKA_1034900   pre-mRNA-splicing factor 38B, putative
Plasmodium falciparum PF3D7_1407300   pre-mRNA-splicing factor 38B, putative
Plasmodium knowlesi PKNH_1350800   pre-mRNA-splicing factor 38B, putative
Plasmodium vivax PVX_086065   pre-mRNA-splicing factor 38B, putative
Plasmodium yoelii PY02472   hypothetical protein
Schistosoma japonicum Sjp_0216490   Pre-mRNA-splicing factor 38B, putative
Schistosoma mansoni Smp_133110   hypothetical protein
Schmidtea mediterranea mk4.003482.14   Pre-mRNA-splicing factor 38B
Schmidtea mediterranea mk4.005830.08   Pre-mRNA-splicing factor 38B
Toxoplasma gondii TGME49_285230   PRP38 family protein
Theileria parva TP04_0792   hypothetical protein, conserved
Theileria parva TP04_0793   hypothetical protein

Essentiality

LOAG_11666 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b4487 Escherichia coli non-essential goodall
PBANKA_1034900 Plasmodium berghei Slow plasmo
TGME49_285230 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_11666 (Loa Loa (eye worm)), PRP38 family protein
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