Detailed view for MUL_0336

Basic information

TDR Targets ID: 953113
Mycobacterium ulcerans, short chain dehydrogenase
Source Database / ID:  KEGG  

pI: 6.4994 | Length (AA): 267 | MW (Da): 27853 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13561   Enoyl-(Acyl carrier protein) reductase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 260 5k9z (B) 10 258 42.00 0 1 1.47374 -0.43
3 258 6f9q (A) 10 261 40.00 0 1 1.4615 -0.62
4 267 5ig2 (A) 3 273 30.00 0 1 1.32396 -0.27
8 189 4dyv (A) 29 206 37.00 0 1 1.09935 -0.07
9 258 3u5t (C) 6 244 43.00 0 1 1.20713 0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129138)

Species Accession Gene Product
Arabidopsis thaliana AT3G26760   Rossmann-fold NAD(P)-binding domain-containing protein
Arabidopsis thaliana AT4G03140   NAD(P)-binding Rossmann-fold superfamily protein
Dictyostelium discoideum DDB_G0284485   short-chain dehydrogenase/reductase family protein
Escherichia coli b2426   furfural resistance protein, putative short-chain oxidoreductase
Homo sapiens 56898   3-hydroxybutyrate dehydrogenase, type 2
Mus musculus ENSMUSG00000028167   3-hydroxybutyrate dehydrogenase, type 2
Mycobacterium tuberculosis Rv2857c   Probable short-chain type dehydrogenase/reductase
Mycobacterium tuberculosis Rv1941   Probable short-chain type dehydrogenase/reductase
Mycobacterium ulcerans MUL_0336   short chain dehydrogenase
Mycobacterium ulcerans MUL_2885   short-chain type dehydrogenase/reductase
Mycobacterium ulcerans MUL_4041   short-chain type dehydrogenase/reductase
Oryza sativa 4344204   Os07g0664300
Oryza sativa 4344201   Os07g0664000
Oryza sativa 4344208   Os07g0665000
Oryza sativa 4344199   Os07g0663800
Oryza sativa 4351918   Os12g0260500
Oryza sativa 4343782   Os07g0592100
Oryza sativa 4344206   Os07g0664500
Oryza sativa 4344198   Os07g0663700
Oryza sativa 4344196   Os07g0663500
Oryza sativa 4344203   Os07g0664200
Oryza sativa 4344197   Os07g0663600
Oryza sativa 4344205   Os07g0664400

Essentiality

MUL_0336 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2426 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bacillus subtilis (strain 168) Enoyl-[acyl-carrier-protein] reductase [NADH] 258 aa 25.9% 243 aa Compounds References
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 29.9% 144 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0256 0.3131 0
0.0026 0.3431 0.3479
0.0184 0.9309 0
0.0256 0.3131 0
0.0243 0.9572 0
0.021 0.8716 0
0.013 0.8847 0.8746
0.0223 0.7904 0.9161
0.0076 0.3786 0.8413
0.0133 0.8786 0.8782

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier MUL_0336 (Mycobacterium ulcerans), short chain dehydrogenase
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