Detailed information for compound 1343024

Basic information

Technical information
  • TDR Targets ID: 1343024
  • Name: 1-methyl-2-[(4-methylpiperazin-1-yl)methyl]in dole-3-carbonitrile
  • MW: 268.357 | Formula: C16H20N4
  • H donors: 0 H acceptors: 1 LogP: 1.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(CN2CCN(CC2)C)n(c2c1cccc2)C
  • InChi: 1S/C16H20N4/c1-18-7-9-20(10-8-18)12-16-14(11-17)13-5-3-4-6-15(13)19(16)2/h3-6H,7-10,12H2,1-2H3
  • InChiKey: PEFIVMPSAKGNOP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-methyl-2-[(4-methyl-1-piperazinyl)methyl]-3-indolecarbonitrile
  • Oprea1_872988
  • 1-Methyl-2-[(4-methyl-1-piperazinyl)methyl]-1H-indole-3-carbonitrile
  • Indole-3-carbonitrile, 1-methyl-2-(4-methyl-1-piperazinylmethyl)-
  • TimTec1_000161
  • EU-0017225
  • ST002182
  • MLS000070293
  • 1-Methyl-2-(4-methyl-piperazin-1-ylmethyl)-1H-indole-3-carbonitrile
  • Oprea1_720074
  • SMR000010562

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.1 0.1265
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.2562 0.3241
Loa Loa (eye worm) hypothetical protein 0.0043 0.1 0.1265
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2562 0.2673
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.8536 0.8373
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0223 0.7904 0.9161
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0223 0.7904 0.9161
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0223 0.7904 0.9214
Brugia malayi hypothetical protein 0.002 0.0085 0.0107
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 0.7904 0.5
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1141 0.0705
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0223 0.7904 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1279 0.0878
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1279 0.0914
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1 0.0531
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0223 0.7904 0.5
Loa Loa (eye worm) retinol dehydrogenase 12 0.0223 0.7904 1
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1279 0.0914
Schistosoma mansoni chromobox protein 0.0084 0.2562 0.2705
Trypanosoma brucei oxidoreductase-like protein 0.024 0.8536 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0223 0.7904 0.7671
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1 0.0676
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0223 0.7904 0.9161
Loa Loa (eye worm) hypothetical protein 0.0032 0.0558 0.0706
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0223 0.7904 0.9214
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0223 0.7904 0.9161
Trypanosoma cruzi oxidoreductase-like protein, putative 0.024 0.8536 1
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Trypanosoma brucei pteridine reductase 1 0.0223 0.7904 0.9214
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0223 0.7904 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1 0.0572
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0223 0.7904 1
Leishmania major hypothetical protein, conserved 0.0043 0.1 0.0623
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Loa Loa (eye worm) hypothetical protein 0.0047 0.1141 0.1444
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0581 0.0735
Toxoplasma gondii ABC1 family protein 0.0043 0.1 0.0623
Onchocerca volvulus 0.0043 0.1 0.0527
Loa Loa (eye worm) hypothetical protein 0.0043 0.1 0.1265
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1 0.1265
Loa Loa (eye worm) hypothetical protein 0.0043 0.1 0.1265
Onchocerca volvulus 0.0043 0.1 0.0527
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0223 0.7904 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0223 0.7904 0.9214
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0223 0.7904 0.7671
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0223 0.7904 1
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0223 0.7904 0.9214
Brugia malayi beta-lactamase 0.0043 0.1 0.1265
Mycobacterium ulcerans oxidoreductase 0.0223 0.7904 0.9161
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0223 0.7904 0.9161
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0223 0.7904 0.9214
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0223 0.7904 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.1 0.1265
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4868 0.6159
Mycobacterium ulcerans short chain dehydrogenase 0.024 0.8536 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0223 0.7904 0.7671
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1141 0.0725
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 0.7904 0.9161
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 0.7904 0.7671
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1 0.0572
Echinococcus granulosus chromobox protein 1 0.0084 0.2562 0.2705
Brugia malayi beta-lactamase family protein 0.0043 0.1 0.1265
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0223 0.7904 0.9161
Brugia malayi MH2 domain containing protein 0.0144 0.4868 0.6159
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.024 0.8536 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4868 0.6159
Echinococcus multilocularis chromobox protein 1 0.0084 0.2562 0.2705
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0223 0.7904 0.9161
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1 0.1265
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 0.7904 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1141 0.0725
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Loa Loa (eye worm) hypothetical protein 0.003 0.0499 0.0631
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0223 0.7904 0.9161
Onchocerca volvulus 0.0223 0.7904 0.9206
Echinococcus granulosus chromobox protein 1 0.0084 0.2562 0.2705
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0223 0.7904 0.9214
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2562 0.2673
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0223 0.7904 0.9161
Leishmania major pteridine reductase 1 0.024 0.8536 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0223 0.7904 0.7671
Brugia malayi beta-lactamase family protein 0.0043 0.1 0.1265
Mycobacterium tuberculosis Possible oxidoreductase 0.0223 0.7904 0.7671
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0223 0.7904 0.9161
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1 0.0623
Loa Loa (eye worm) hypothetical protein 0.0223 0.7904 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.2562 0.2705
Onchocerca volvulus 0.0037 0.075 0.0213
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 0.7904 0.9214
Onchocerca volvulus 0.0043 0.1 0.0527
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0223 0.7904 0.9161
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 0.7904 1
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0223 0.7904 0.9161
Brugia malayi hypothetical protein 0.003 0.0499 0.0631
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0223 0.7904 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0223 0.7904 0.7671
Chlamydia trachomatis oxoacy-ACP reductase 0.0223 0.7904 0.5
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0223 0.7904 0.7671
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0223 0.7904 1
Schistosoma mansoni chromobox protein 0.0084 0.2562 0.2705
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0581 0.0735
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 0.7904 1
Schistosoma mansoni dihydropteridine reductase 0.0223 0.7904 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0223 0.7904 0.9214
Trichomonas vaginalis esterase, putative 0.0043 0.1 0.0531
Brugia malayi chromobox protein homolog 3 0.0047 0.1141 0.1444
Loa Loa (eye worm) oxidoreductase 0.0223 0.7904 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0223 0.7904 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1 0.0531
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0223 0.7904 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1 0.0531
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1 0.0531
Loa Loa (eye worm) hypothetical protein 0.0033 0.0581 0.0735
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0223 0.7904 0.9161
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.024 0.8536 1
Brugia malayi Heterochromatin protein 1 0.0084 0.2562 0.3241
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0581 0.0735
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0223 0.7904 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0223 0.7904 1
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.024 0.8536 1
Loa Loa (eye worm) beta-lactamase 0.0043 0.1 0.1265
Mycobacterium tuberculosis Possible oxidoreductase 0.0223 0.7904 0.7671
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1 0.0623
Loa Loa (eye worm) hypothetical protein 0.0037 0.075 0.0949
Loa Loa (eye worm) hypothetical protein 0.0043 0.1 0.1265
Onchocerca volvulus 0.024 0.8536 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0223 0.7904 0.9161
Leishmania major oxidoreductase-like protein 0.024 0.8536 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.024 0.8536 1
Mycobacterium ulcerans short chain dehydrogenase 0.0223 0.7904 0.9161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1 0.0572
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1 0.0531
Trichomonas vaginalis hypothetical protein 0.0223 0.7904 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1 0.0623
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0223 0.7904 0.9214
Brugia malayi intermediate filament protein 0.0033 0.0581 0.0735
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1 0.0572

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1259 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2512 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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