Detailed view for EmuJ_000799100

Basic information

TDR Targets ID: 956726
Echinococcus multilocularis, C2 calcium dependent membrane targeting

Source Database / ID:  GeneDB

pI: 6.7394 | Length (AA): 1080 | MW (Da): 119375 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 146 1djx (A) 628 755 23.00 0 0.85 0.32087 -0.35
18 145 3kwt (A) 689 819 32.00 0.000011 1 0.352919 0.19
40 102 4y1s (A) 434 494 38.00 0.78 0.63 0.348733 0.46
164 263 1y2i (A) 6 108 20.00 0 0.55 0.295093 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130428)

Species Accession Gene Product
Brugia malayi Bm1_00685   C2 domain containing protein
Caenorhabditis elegans CELE_F52H2.7   Protein F52H2.7
Dictyostelium discoideum DDB_G0269546   C2 calcium-dependent membrane targeting domain-containing protein
Drosophila melanogaster Dmel_CG6454   CG6454 gene product from transcript CG6454-RC
Echinococcus granulosus EgrG_000799100   C2 calcium dependent membrane targeting
Echinococcus multilocularis EmuJ_000799100   C2 calcium dependent membrane targeting
Homo sapiens ENSG00000111731   C2 calcium-dependent domain containing 5
Leishmania braziliensis LbrM.13.0580   hypothetical protein, conserved
Leishmania donovani LdBPK_130650.1   C2 domain containing protein, putative
Leishmania infantum LinJ.13.0650   hypothetical protein, conserved
Leishmania major LmjF.13.0760   hypothetical protein, conserved
Leishmania mexicana LmxM.13.0760   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_06395   C2 domain-containing protein
Mus musculus ENSMUSG00000030279   C2 calcium-dependent domain containing 5
Onchocerca volvulus OVOC5589  
Plasmodium berghei PBANKA_0305200   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0208100   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0413000   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_003855   hypothetical protein, conserved
Plasmodium yoelii PY06292   fulmal1
Plasmodium yoelii PY03495   hypothetical protein
Schistosoma japonicum Sjp_0044000   Conserved hypothetical protein
Schistosoma japonicum Sjp_0131600   similar to Uncharacterized protein KIAA0528 homolog, putative
Schistosoma japonicum Sjp_0314790   similar to Uncharacterized protein KIAA0528 homolog, putative
Schistosoma mansoni Smp_133590   hypothetical protein
Schmidtea mediterranea mk4.020079.02  
Schmidtea mediterranea mk4.028373.00  
Schmidtea mediterranea mk4.018587.00  
Schmidtea mediterranea mk4.008967.01  
Schmidtea mediterranea mk4.025011.01  
Schmidtea mediterranea mk4.018071.01  
Trypanosoma brucei gambiense Tbg972.11.4750   hypothetical protein, conserved,predicted C2 domain protein
Trypanosoma brucei Tb927.11.4160   predicted C2 domain protein
Trypanosoma congolense TcIL3000.11.4200   predicted C2 domain protein
Trypanosoma cruzi TcCLB.506737.40   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511855.50   hypothetical protein, conserved

Essentiality

EmuJ_000799100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.1630 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.1630 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.1630 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.1630 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F52H2.7 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0058 0.5 0.5
0.005 0.2612 0.2612
0.0057 0.3491 0.3491
0.0072 0.2639 0.2639
0.0121 1 1
0.0018 0.5 0.5
0.0071 0.2549 0.2498
0.0125 0.3893 0.9758
0.0107 0.5 0.5
0.0109 0.4866 0.4866

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000799100 (Echinococcus multilocularis), C2 calcium dependent membrane targeting
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