Detailed view for EmuJ_000205300

Basic information

TDR Targets ID: 959487
Echinococcus multilocularis, phosphorylase b kinase regulatory
Source Database / ID:  GeneDB

pI: 6.9528 | Length (AA): 1206 | MW (Da): 136870 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00723   Glycosyl hydrolases family 15

Gene Ontology

Mouse over links to read term descriptions.
GO:0005516   calmodulin binding  
GO:0003824   catalytic activity  
GO:0005977   glycogen metabolic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133461)

Species Accession Gene Product
Brugia malayi Bm1_29510   phosphorylase B kinase beta regulatory chain
Caenorhabditis elegans CELE_Y67D8A.2   Protein Y67D8A.2, isoform C
Drosophila melanogaster Dmel_CG8475   CG8475 gene product from transcript CG8475-RC
Echinococcus granulosus EgrG_000205300   phosphorylase b kinase regulatory
Echinococcus multilocularis EmuJ_000205300   phosphorylase b kinase regulatory
Homo sapiens ENSG00000102893   phosphorylase kinase, beta
Loa Loa (eye worm) LOAG_11446   hypothetical protein
Mus musculus ENSMUSG00000036879   phosphorylase kinase beta
Onchocerca volvulus OVOC5647   Phosphorylase b kinase regulatory subunit beta homolog
Schistosoma japonicum Sjp_0206700   Probable phosphorylase b kinase regulatory subunit beta, putative
Schistosoma japonicum Sjp_0206710   Phosphorylase b kinase regulatory subunit beta, putative
Schistosoma japonicum Sjp_0311020   Probable phosphorylase b kinase regulatory subunit beta, putative
Schistosoma mansoni Smp_161680   phosphorylase B kinase beta kpbb
Schmidtea mediterranea mk4.002535.09  
Schmidtea mediterranea mk4.002359.01   Phosphorylase b kinase regulatory subunit beta

Essentiality

EmuJ_000205300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y67D8A.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphorylase kinase, beta Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0576 0.3083 0.3066
0.0367 0.6291 0.627
0.0319 0.6319 0.6104
0.0662 0.4757 0.4757
0.0712 0.2792 0.2792
0.0617 0.3569 0.3569
0.0712 0.2792 0.2792
0.0339 0.6334 0.6134
0.0663 0.2529 0.2295
0.0634 0.2515 0.2513
0.0712 0.333 0.333
0.0684 0.3748 0.3748
0.0662 0.4757 0.4757

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000205300 (Echinococcus multilocularis), phosphorylase b kinase regulatory
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