pI: 7.5314 |
Length (AA): 308 |
MW (Da): 35148 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
17 | 61 | 5vak (A) | 233 | 277 | 36.00 | 0.82 | 0.12 | 0.0426039 | 2.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128204)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G04930 | sphingolipid delta-4 desaturase |
Brugia malayi | Bm1_54630 | Fatty acid desaturase family protein |
Candida albicans | CaO19.11530 | sphingolipid delta 4 desaturase similar to S. pombe dsd1 (SPBC3B8.07c) |
Candida albicans | CaO19.4048 | sphingolipid delta 4 desaturase similar to S. pombe dsd1 (SPBC3B8.07c) |
Caenorhabditis elegans | CELE_Y54E5A.1 | Protein TTM-5 |
Caenorhabditis elegans | CELE_F33D4.4 | Protein F33D4.4 |
Dictyostelium discoideum | DDB_G0269738 | dihydroceramide desaturase |
Drosophila melanogaster | Dmel_CG9078 | infertile crescent |
Echinococcus granulosus | EgrG_002000500 | Fatty acid desaturase type 1 |
Echinococcus multilocularis | EmuJ_000357100 | Peptidase M, neutral zinc metallopeptidases, zinc binding site |
Echinococcus multilocularis | EmuJ_000346400 | Sphingolipid delta(4) desaturase DES1 |
Echinococcus multilocularis | EmuJ_000357200 | Peptidase M, neutral zinc metallopeptidases, zinc binding site |
Echinococcus multilocularis | EmuJ_000006800 | Fatty acid desaturase, type 1 |
Homo sapiens | ENSG00000143753 | delta(4)-desaturase, sphingolipid 1 |
Homo sapiens | 123099 | delta(4)-desaturase, sphingolipid 2 |
Leishmania braziliensis | LbrM.23.1980 | fatty acid desaturase |
Leishmania infantum | LinJ.26.1680 | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative |
Leishmania major | LmjF.26.1670 | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative |
Leishmania major | LmjF.26.1690 | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative |
Leishmania major | LmjF.26.1700 | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative |
Leishmania major | LmjF.26.1680 | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative |
Leishmania mexicana | LmxM.26.1700 | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative |
Leishmania mexicana | LmxM.26.1670 | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative |
Leishmania mexicana | LmxM.26.1690 | |
Loa Loa (eye worm) | LOAG_10890 | fatty acid desaturase |
Mus musculus | ENSMUSG00000038633 | degenerative spermatocyte homolog 1 (Drosophila) |
Mus musculus | ENSMUSG00000021263 | degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase |
Neospora caninum | NCLIV_051070 | membrane fatty acid desaturase, putative |
Oryza sativa | 4330104 | Os02g0639600 |
Schistosoma japonicum | Sjp_0317130 | expressed protein |
Schmidtea mediterranea | mk4.001493.02 | Dihydroceramide desaturase |
Schmidtea mediterranea | mk4.021730.00 | |
Schmidtea mediterranea | mk4.021680.00 | Putative sphingolipid delta(4)-desaturase/C4-hydroxylase |
Trypanosoma brucei gambiense | Tbg972.6.2790 | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative |
Trypanosoma brucei | Tb927.6.3000 | sphingolipid delta 4 desaturase, putative |
Trypanosoma congolense | TcIL3000_6_2510 | sphingolipid delta 4 desaturase, putative |
Trypanosoma cruzi | TcCLB.510565.20 | fatty acid desaturase, putative |
Toxoplasma gondii | TGME49_237200 | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.3000 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.3000 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.3000 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.3000 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_237200 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | delta(4)-desaturase, sphingolipid 1 | Compounds | References |