Detailed view for EmuJ_000594000

Basic information

TDR Targets ID: 960952
Echinococcus multilocularis, NADH dehydrogenase (ubiquinone) 1 alpha
Source Database / ID:  GeneDB

pI: 10.1235 | Length (AA): 157 | MW (Da): 17973 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07347   NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008137   NADH dehydrogenase (ubiquinone) activity  
GO:0005743   mitochondrial inner membrane  
GO:0042773   ATP synthesis coupled electron transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 73 5hl3 (A) 192 252 30.00 0.34 0.34 0.510735 1.4
87 136 4e5r (A) 301 354 24.00 0 0.2 0.514671 -0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133710)

Species Accession Gene Product
Brugia malayi Bm1_35470   hypothetical protein
Caenorhabditis elegans CELE_F45H10.3   Protein F45H10.3
Drosophila melanogaster Dmel_CG6914   CG6914 gene product from transcript CG6914-RA
Drosophila melanogaster Dmel_CG3621   CG3621 gene product from transcript CG3621-RB
Echinococcus granulosus EgrG_000594000   NADH dehydrogenase ubiquinone 1 alpha
Echinococcus multilocularis EmuJ_000594000   NADH dehydrogenase (ubiquinone) 1 alpha
Homo sapiens ENSG00000267855   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
Loa Loa (eye worm) LOAG_08136   hypothetical protein
Mus musculus ENSMUSG00000041881   NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
Onchocerca volvulus OVOC11587  
Schistosoma japonicum Sjp_0210290   ko:K03951 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 7, putative
Schistosoma mansoni Smp_019730.2   hypothetical protein
Schistosoma mansoni Smp_019730.1   hypothetical protein
Schmidtea mediterranea mk4.003867.02  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0482 0.2883 0.3041
0.0477 0.3545 0.5056
0.0482 0.3068 0.3068
0.0492 0.304 0.304
0.0235 0.2857 0.2816
0.0482 0.2883 0.3041
0.024 0.2857 0.2816
0.0279 0.2857 0.2816
0.024 0.2857 0.2816
0.0473 0.3529 0.5027
0.0472 0.275 0.29
0.0233 0.2831 0.2816
0.0488 0.35 0.4787
0.0474 0.2854 0.2853
0.0233 0.2831 0.2816
0.0503 0.3067 0.304
0.0492 0.2944 0.2944
0.0279 0.3315 0.5667
0.0468 0.3788 0.538
0.0499 0.3488 0.483
0.0235 0.2857 0.2816
0.0226 0.2931 0.292
0.0498 0.3005 0.2985
0.0467 0.3501 0.586
0.0468 0.3788 0.538
0.0509 0.3047 0.3042
0.0465 0.3486 0.4942
0.0521 0.3107 0.3071
0.0472 0.3511 0.3747
0.0478 0.3537 0.512

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000594000 (Echinococcus multilocularis), NADH dehydrogenase (ubiquinone) 1 alpha
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