Detailed view for EmuJ_000417700

Basic information

TDR Targets ID: 961166
Echinococcus multilocularis, protein phosphatase 1 catalytic subunit
Source Database / ID:  GeneDB

pI: 5.2061 | Length (AA): 411 | MW (Da): 46407 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase
PF16891   Serine-threonine protein phosphatase N-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 379 4ja7 (A) 103 475 26.00 0.0000000095 1 1.19947 -0.37
61 399 1s70 (A) 2 304 58.00 0 1 1.48902 -1.19
64 396 5jpe (A) 169 478 51.00 0.00000000013 1 1.46842 -1.43
79 370 1aui (A) 47 327 37.00 0 1 1.19576 -1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126821)

Species Accession Gene Product
Arabidopsis thaliana AT5G59160   serine/threonine-protein phosphatase PP1 isozyme 2
Arabidopsis thaliana AT4G11240   serine/threonine-protein phosphatase PP1 isozyme 6
Arabidopsis thaliana AT1G64040   serine/threonine-protein phosphatase 3
Arabidopsis thaliana AT5G43380   type one serine/threonine protein phosphatase 6
Arabidopsis thaliana AT3G46820   serine/threonine-protein phosphatase PP1 isozyme 5
Arabidopsis thaliana AT2G39840   serine/threonine-protein phosphatase PP1 isozyme 4
Babesia bovis BBOV_III006130   Ser/Thr protein phosphatase family protein
Brugia malayi Bm1_12875   Serine/threonine protein phosphatase PP1-beta catalytic subunit
Brugia malayi Bm1_19675   Serine/threonine protein phosphatase F56C9.1 in chromosomeIII
Candida albicans CaO19.6285   potential calcineurin-like phosphoesterase similar to S. cerevisiae GLC7 (YER133W) protein phosphatase involved in glycogen accu
Candida albicans CaO19.13664   potential calcineurin-like phosphoesterase similar to S. cerevisiae GLC7 (YER133W) protein phosphatase involved in glycogen accu
Caenorhabditis elegans CELE_F29F11.6   Protein GSP-1, isoform B
Caenorhabditis elegans CELE_F56C9.1   Protein GSP-2
Cryptosporidium hominis Chro.70303   hypothetical protein
Cryptosporidium parvum cgd7_2670   serine/threonine protein phosphatase, putative
Dictyostelium discoideum DDB_G0275619   protein phosphatase 1, catalytic subunit
Drosophila melanogaster Dmel_CG5650   Protein phosphatase 1 at 87B
Drosophila melanogaster Dmel_CG9156   Protein phosphatase 1 at 13C
Drosophila melanogaster Dmel_CG2096   flapwing
Drosophila melanogaster Dmel_CG6593   Protein phosphatase 1alpha at 96A
Drosophila melanogaster Dmel_CG41534   CG41534 gene product from transcript CG41534-RC
Echinococcus granulosus EgrG_000697500   protein phosphatase 1, catalytic subunit, beta isozyme
Echinococcus granulosus EgrG_000206600   serine:threonine protein phosphatase
Echinococcus granulosus EgrG_000886600   protein phosphatase 1 catalytic subunit
Echinococcus granulosus EgrG_001031100   serine:threonine protein phosphatase PP1 gamma
Echinococcus granulosus EgrG_000779500   serine:threonine protein phosphatase PP1 gamma
Echinococcus granulosus EgrG_000417700   protein phosphatase 1 catalytic subunit
Echinococcus granulosus EgrG_000522800   serine:threonine protein phosphatase PP1 beta
Entamoeba histolytica EHI_176170   serine/threonine protein phosphatase PP1-2, putative
Entamoeba histolytica EHI_048970   serine/threonine protein phosphatase PP1-2, putative
Echinococcus multilocularis EmuJ_000522800   serine:threonine protein phosphatase PP1 beta
Echinococcus multilocularis EmuJ_000779500   serine:threonine protein phosphatase PP1 gamma
Echinococcus multilocularis EmuJ_000886600   protein phosphatase 1 catalytic subunit
Echinococcus multilocularis EmuJ_000206600   Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase
Echinococcus multilocularis EmuJ_000206500   Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase
Echinococcus multilocularis EmuJ_001031100   serine:threonine protein phosphatase PP1 gamma
Echinococcus multilocularis EmuJ_000697500   serine:threonine protein phosphatase PP1 isozyme
Echinococcus multilocularis EmuJ_000417700   protein phosphatase 1 catalytic subunit
Giardia lamblia GL50803_15215   Phosphatase
Giardia lamblia GL50803_14568   Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit
Homo sapiens ENSG00000213639   protein phosphatase 1, catalytic subunit, beta isozyme
Homo sapiens ENSG00000186298   protein phosphatase 1, catalytic subunit, gamma isozyme
Homo sapiens ENSG00000172531   protein phosphatase 1, catalytic subunit, alpha isozyme
Leishmania braziliensis LbrM.28.0710   serine/threonine protein phosphatase catalytic subunit, putative
Leishmania donovani LdBPK_280730.1   serine/threonine protein phosphatase catalytic subunit, putative
Leishmania infantum LinJ.28.0730   serine/threonine protein phosphatase catalytic subunit, putative
Leishmania major LmjF.28.0690   serine/threonine protein phosphatase catalytic subunit, putative
Leishmania mexicana LmxM.28.0690   serine/threonine protein phosphatase catalytic subunit, putative
Loa Loa (eye worm) LOAG_04559   hypothetical protein
Loa Loa (eye worm) LOAG_06374   serine/threonine protein phosphatase PP1-beta catalytic subunit
Loa Loa (eye worm) LOAG_09251   serine/threonine-protein phosphatase PP1-beta
Mus musculus ENSMUSG00000004455   protein phosphatase 1, catalytic subunit, gamma isoform
Mus musculus 19046   protein phosphatase 1, catalytic subunit, beta isoform
Mus musculus ENSMUSG00000040385   protein phosphatase 1, catalytic subunit, alpha isoform
Neospora caninum NCLIV_054750   hypothetical protein
Oryza sativa 4340228   Os06g0164100
Oryza sativa 4332369   Os03g0268000
Oryza sativa 4331166   Os02g0820000
Plasmodium berghei PBANKA_1028300   serine/threonine protein phosphatase PP1
Plasmodium falciparum PF3D7_1414400   serine/threonine protein phosphatase PP1
Plasmodium knowlesi PKNH_1343700   serine/threonine protein phosphatase PP1, putative
Plasmodium vivax PVX_085730   serine/threonine protein phosphatase PP1, putative
Plasmodium yoelii PY07156   serine/threonine protein phosphatase alpha-3 isoform
Saccharomyces cerevisiae YER133W   type 1 serine/threonine-protein phosphatase catalytic subunit GLC7
Schistosoma japonicum Sjp_0033580   ko:K06269 protein phosphatase 1, catalytic subunit, putative
Schistosoma japonicum Sjp_0016700   ko:K06269 protein phosphatase 1, catalytic subunit, putative
Schistosoma japonicum Sjp_0213050   ko:K06269 protein phosphatase 1, catalytic subunit, putative
Schistosoma mansoni Smp_028990.1   protein phosphatase-1
Schistosoma mansoni Smp_035580   protein phosphatase-1
Schistosoma mansoni Smp_004810.1   protein phosphatase type 1
Schistosoma mansoni Smp_004810.3   protein phosphatase type 1
Schmidtea mediterranea mk4.015781.02  
Schmidtea mediterranea mk4.001639.02   FI07629p
Schmidtea mediterranea mk4.000395.04  
Schmidtea mediterranea mk4.012344.00  
Schmidtea mediterranea mk4.000218.03  
Schmidtea mediterranea mk4.022592.01  
Schmidtea mediterranea mk4.001270.03  
Schmidtea mediterranea mk4.002462.02   FI07629p
Schmidtea mediterranea mk4.000863.05  
Schmidtea mediterranea mk4.000264.00  
Schmidtea mediterranea mk4.000329.11  
Schmidtea mediterranea mk4.004153.01   Serine/threonine-protein phosphatase PP1-alpha
Schmidtea mediterranea mk4.000693.03  
Schmidtea mediterranea mk4.006343.01   FI07629p
Schmidtea mediterranea mk4.025263.01  
Schmidtea mediterranea mk4.016959.00   FI07629p
Schmidtea mediterranea mk4.001881.01  
Schmidtea mediterranea mk4.000779.08  
Schmidtea mediterranea mk4.007605.00  
Schmidtea mediterranea mk4.000538.10  
Schmidtea mediterranea mk4.000273.08  
Schmidtea mediterranea mk4.020744.01  
Schmidtea mediterranea mk4.008245.00  
Schmidtea mediterranea mk4.013283.02  
Schmidtea mediterranea mk4.001325.03  
Schmidtea mediterranea mk4.001293.11  
Schmidtea mediterranea mk4.001330.03  
Schmidtea mediterranea mk4.003352.00  
Schmidtea mediterranea mk4.000453.08   FI07629p
Schmidtea mediterranea mk4.003016.01   FI07629p
Schmidtea mediterranea mk4.003837.00  
Schmidtea mediterranea mk4.008687.00  
Schmidtea mediterranea mk4.000225.02  
Schmidtea mediterranea mk4.001749.02  
Schmidtea mediterranea mk4.023586.02  
Schmidtea mediterranea mk4.012019.02  
Schmidtea mediterranea mk4.024594.00  
Schmidtea mediterranea mk4.002755.07  
Schmidtea mediterranea mk4.001796.03   Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Schmidtea mediterranea mk4.006022.00  
Schmidtea mediterranea mk4.018736.00  
Schmidtea mediterranea mk4.015537.01  
Schmidtea mediterranea mk4.000432.03  
Schmidtea mediterranea mk4.000221.09  
Schmidtea mediterranea mk4.001819.05  
Schmidtea mediterranea mk4.023531.00  
Schmidtea mediterranea mk4.004286.00  
Schmidtea mediterranea mk4.008079.01  
Schmidtea mediterranea mk4.017165.01  
Schmidtea mediterranea mk4.000077.14  
Schmidtea mediterranea mk4.001841.00  
Schmidtea mediterranea mk4.014938.00  
Schmidtea mediterranea mk4.003101.00  
Schmidtea mediterranea mk4.000344.12  
Schmidtea mediterranea mk4.008007.01  
Schmidtea mediterranea mk4.014132.01  
Schmidtea mediterranea mk4.003773.04  
Schmidtea mediterranea mk4.000538.11  
Schmidtea mediterranea mk4.012902.00  
Schmidtea mediterranea mk4.007849.05  
Schmidtea mediterranea mk4.003093.02  
Schmidtea mediterranea mk4.003856.00  
Schmidtea mediterranea mk4.007536.03  
Schmidtea mediterranea mk4.000460.09  
Schmidtea mediterranea mk4.018450.01  
Schmidtea mediterranea mk4.001226.03  
Schmidtea mediterranea mk4.002695.00  
Schmidtea mediterranea mk4.000093.04   FI07629p
Schmidtea mediterranea mk4.014725.00  
Schmidtea mediterranea mk4.033964.00  
Schmidtea mediterranea mk4.026379.00  
Schmidtea mediterranea mk4.018162.00  
Schmidtea mediterranea mk4.010744.00  
Schmidtea mediterranea mk4.005018.00   FI07629p
Schmidtea mediterranea mk4.018246.00  
Schmidtea mediterranea mk4.000012.20   Serine/threonine-protein phosphatase PP1-beta
Schmidtea mediterranea mk4.008758.00   FI07629p
Schmidtea mediterranea mk4.015161.00  
Schmidtea mediterranea mk4.022181.01  
Schmidtea mediterranea mk4.003449.02  
Schmidtea mediterranea mk4.031085.00  
Schmidtea mediterranea mk4.002149.06  
Schmidtea mediterranea mk4.014407.00  
Schmidtea mediterranea mk4.000219.19  
Schmidtea mediterranea mk4.001803.09  
Schmidtea mediterranea mk4.007137.01  
Schmidtea mediterranea mk4.020468.00  
Schmidtea mediterranea mk4.008210.01  
Schmidtea mediterranea mk4.000648.10  
Schmidtea mediterranea mk4.003496.04  
Schmidtea mediterranea mk4.020340.00  
Schmidtea mediterranea mk4.018523.00  
Schmidtea mediterranea mk4.031312.00  
Schmidtea mediterranea mk4.001537.00   FI07629p
Schmidtea mediterranea mk4.001938.00  
Schmidtea mediterranea mk4.003069.04  
Schmidtea mediterranea mk4.010546.01  
Schmidtea mediterranea mk4.005941.01   FI07629p
Schmidtea mediterranea mk4.001027.06  
Schmidtea mediterranea mk4.000250.02  
Schmidtea mediterranea mk4.000560.17   FI07629p
Schmidtea mediterranea mk4.006042.00  
Schmidtea mediterranea mk4.007439.00  
Schmidtea mediterranea mk4.007086.01   Pp1-Y2
Schmidtea mediterranea mk4.005089.00   Pp1-Y2
Schmidtea mediterranea mk4.003837.01  
Schmidtea mediterranea mk4.001924.02  
Schmidtea mediterranea mk4.024474.00  
Schmidtea mediterranea mk4.020140.00  
Schmidtea mediterranea mk4.001938.01   Serine/threonine-protein phosphatase PP1-beta
Schmidtea mediterranea mk4.016143.01  
Schmidtea mediterranea mk4.001587.00  
Trypanosoma brucei gambiense Tbg972.11.9250   serine/threonine protein phosphatase catalytic subunit, putative,serine/threonine protein phosphatase PP1-gamma
Trypanosoma brucei Tb927.11.8090   protein phosphatase 1, putative
Trypanosoma congolense TcIL3000.11.8600   protein phosphatase 1, putative
Trypanosoma cruzi TcCLB.508815.110   serine/threonine protein phosphatase catalytic subunit, putative
Toxoplasma gondii TGME49_310700   serine/threonine phosophatase PP1
Theileria parva TP02_0350   serine/threonine protein phosphatase, putative
Trichomonas vaginalis TVAG_402150   bsu-protein phosphatase, putative
Trichomonas vaginalis TVAG_256320   protein phosphatase, caeel, putative
Trichomonas vaginalis TVAG_146890   bsu-protein phosphatase, putative
Trichomonas vaginalis TVAG_087120   protein phosphatase-1, putative
Trichomonas vaginalis TVAG_379450   bsu-protein phosphatase, putative
Trichomonas vaginalis TVAG_202660   protein phosphatase 2A, caeel, putative
Trichomonas vaginalis TVAG_101240   serine/threonine protein phosphatase, putative
Trichomonas vaginalis TVAG_192070   serine/threonine protein phosphatase, putative

Essentiality

EmuJ_000417700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.0450 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.0450 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.0450 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F29F11.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F29F11.6 Caenorhabditis elegans larval lethal wormbase
CELE_F29F11.6 Caenorhabditis elegans sterile wormbase
CELE_F56C9.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F56C9.1 Caenorhabditis elegans slow growth wormbase
YER133W Saccharomyces cerevisiae inviable yeastgenome
TGME49_310700 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein phosphatase 1, catalytic subunit, gamma isozyme Compounds References
Homo sapiens protein phosphatase 1, catalytic subunit, alpha isozyme Compounds References
Oryctolagus cuniculus Serine/threonine protein phosphatase PP1-alpha catalytic subunit Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 159 aa 46.8% 171 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 49.7% 300 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 169 aa 49.7% 175 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 297 aa 49.8% 295 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 49.7% 300 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 beta 330 aa 47.9% 290 aa Compounds References
Bos taurus Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform 309 aa 41.2% 301 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 351 aa 51.5% 309 aa Compounds References
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 294 aa 49.7% 292 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier EmuJ_000417700 (Echinococcus multilocularis), protein phosphatase 1 catalytic subunit
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