pI: 5.5936 |
Length (AA): 1242 |
MW (Da): 139847 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 55 | 2dnc (A) | 8 | 59 | 17.00 | 0.0012 | 0.15 | 0.245773 | -0.6 |
6 | 57 | 1iyu (A) | 2 | 52 | 24.00 | 0.37 | 0.14 | 0.263968 | -0.1 |
11 | 58 | 1o78 (A) | 16 | 64 | 33.00 | 0.1 | 0.47 | 0.345747 | -0.22 |
145 | 293 | 4xpz (A) | 163 | 325 | 47.00 | 0 | 1 | 0.633368 | -0.7 |
354 | 1173 | 4bxh (A) | 10 | 822 | 9.00 | 0 | 0.06 | 0.602425 | 0.71 |
873 | 1032 | 5cwh (A) | 2 | 155 | 14.00 | 0 | 0.06 | 0.294024 | -1.02 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129170)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G58003 | C-terminal domain phosphatase-like 4 |
Brugia malayi | Bm1_14230 | NLI interacting factor-like phosphatase family protein |
Candida albicans | CaO19.14034 | similar to S. cerevisiae FCP1 (YMR277W) TFIIF interacting Component of CTD Phosphatase |
Candida albicans | CaO19.6742 | similar to S. cerevisiae FCP1 (YMR277W) TFIIF interacting Component of CTD Phosphatase |
Caenorhabditis elegans | CELE_F36F2.6 | Protein FCP-1 |
Dictyostelium discoideum | DDB_G0271690 | hypothetical protein |
Drosophila melanogaster | Dmel_CG12252 | CG12252 gene product from transcript CG12252-RB |
Echinococcus granulosus | EgrG_000495900 | RNA polymerase II subunit A C terminal domain |
Echinococcus granulosus | EgrG_000185200 | RNA polymerase II subunit A C terminal domain |
Echinococcus multilocularis | EmuJ_000372500 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000495900 | RNA polymerase II subunit A C terminal domain |
Echinococcus multilocularis | EmuJ_000185200 | RNA polymerase II subunit A C terminal domain |
Homo sapiens | ENSG00000060069 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
Loa Loa (eye worm) | LOAG_00540 | hypothetical protein |
Mus musculus | ENSMUSG00000033323 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
Neospora caninum | NCLIV_045130 | hypothetical protein |
Oryza sativa | 4338679 | Os05g0390500 |
Saccharomyces cerevisiae | YMR277W | Fcp1p |
Schistosoma japonicum | Sjp_0072470 | ko:K01090 protein phosphatase [EC3.1.3.16], putative |
Schistosoma mansoni | Smp_131560 | rna polymerase II ctd phosphatase |
Schmidtea mediterranea | mk4.003305.02 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.001217.03 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.021572.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.004264.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.016013.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.021388.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.002268.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.022267.02 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.010734.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.020918.00 | |
Schmidtea mediterranea | mk4.000051.03 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.003579.04 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.003768.04 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.004966.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.000854.10 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.009388.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.022381.00 | |
Schmidtea mediterranea | mk4.012474.00 | RNA polymerase II subunit A C-terminal domain phosphatase |
Schmidtea mediterranea | mk4.000365.06 | RNA polymerase II subunit A C-terminal domain phosphatase |
Toxoplasma gondii | TGME49_228330 | NLI interacting factor family phosphatase |
Trichomonas vaginalis | TVAG_095200 | RNA polymerase II ctd phosphatase, putative |
Trichomonas vaginalis | TVAG_206010 | RNA polymerase II ctd phosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F36F2.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
YMR277W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_228330 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.