pI: 6.6362 |
Length (AA): 711 |
MW (Da): 77506 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 152 | 4k6j (A) | 871 | 1042 | 10.00 | 0 | 0.03 | 0.222125 | -0.13 |
18 | 57 | 4cgb (A) | 14 | 53 | 40.00 | 0 | 0.13 | 0.422259 | 0.22 |
56 | 151 | 2mqa (A) | 22 | 117 | 17.00 | 0 | 0.01 | 0.370021 | -0.89 |
156 | 710 | 4ci8 (A) | 176 | 815 | 53.00 | 0 | 1 | 1.24839 | -0.14 |
520 | 594 | 2hes (X) | 102 | 180 | 28.00 | 0.0017 | 0.91 | 0.522285 | -0.62 |
527 | 595 | 5nuv (A) | 540 | 605 | 30.00 | 0.067 | 0.95 | 0.493846 | -0.58 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129133)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_14480 | HELP domain containing protein |
Caenorhabditis elegans | CELE_F38A6.2 | Protein ELP-1, isoform B |
Drosophila melanogaster | Dmel_CG42247 | Doublecortin-domain-containing echinoderm-microtubule-associated protein ortholog |
Echinococcus granulosus | EgrG_000144700 | echinoderm microtubule associated protein1 |
Echinococcus granulosus | EgrG_002071300 | echinoderm microtubule associated protein |
Echinococcus multilocularis | EmuJ_000139600 | echinoderm microtubule associated protein |
Echinococcus multilocularis | EmuJ_000144700 | echinoderm microtubule associated protein1 |
Homo sapiens | ENSG00000066629 | echinoderm microtubule associated protein like 1 |
Homo sapiens | ENSG00000149499 | echinoderm microtubule associated protein like 3 |
Homo sapiens | ENSG00000143924 | echinoderm microtubule associated protein like 4 |
Homo sapiens | ENSG00000125746 | echinoderm microtubule associated protein like 2 |
Loa Loa (eye worm) | LOAG_07893 | hypothetical protein |
Mus musculus | ENSMUSG00000058070 | echinoderm microtubule associated protein like 1 |
Mus musculus | ENSMUSG00000040811 | echinoderm microtubule associated protein like 2 |
Mus musculus | ENSMUSG00000032624 | echinoderm microtubule associated protein like 4 |
Mus musculus | ENSMUSG00000071647 | echinoderm microtubule associated protein like 3 |
Schistosoma japonicum | Sjp_0050030 | expressed protein |
Schistosoma japonicum | Sjp_0096250 | similar to 77 kDa echinoderm microtubule-associated protein, putative |
Schistosoma japonicum | Sjp_0091140 | Echinoderm microtubule-associated protein-like 1, putative |
Schistosoma mansoni | Smp_163210 | hypothetical protein |
Schmidtea mediterranea | mk4.000552.08 | Echinoderm microtubule-associated protein-like CG42247 |
Schmidtea mediterranea | mk4.002323.04 | Echinoderm microtubule-associated protein-like elp-1 |
Schmidtea mediterranea | mk4.000292.10 | Echinoderm microtubule-associated protein-like elp-1 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | echinoderm microtubule associated protein like 4 | Compounds | References |