pI: 6.5035 |
Length (AA): 539 |
MW (Da): 58812 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 528 | 4b2t (G) | 7 | 525 | 68.00 | 0 | 1 | 1.66622 | -0.07 |
14 | 131 | 4b2t (D) | 29 | 146 | 47.00 | 0.23 | 0.98 | 0.811624 | -0.58 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127483)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G26360 | TCP-1/cpn60 chaperonin family protein |
Babesia bovis | BBOV_III002780 | TCP-1/cpn60 chaperonin family protein |
Brugia malayi | Bm1_09595 | T-complex protein 1, gamma subunit |
Candida albicans | CaO19.11487 | similar to S. cerevisiae CCT3 (YJL014W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Candida albicans | CaO19.4004 | similar to S. cerevisiae CCT3 (YJL014W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Caenorhabditis elegans | CELE_F54A3.3 | Protein CCT-3 |
Cryptosporidium hominis | Chro.40439 | CCT chaperonin gamma subunit |
Cryptosporidium parvum | cgd4_3850 | putative t-complex protein 1, gamma subunit |
Dictyostelium discoideum | DDB_G0281741 | chaperonin containing TCP1 gamma subunit |
Drosophila melanogaster | Dmel_CG8977 | CG8977 gene product from transcript CG8977-RB |
Echinococcus granulosus | EgrG_000872100 | t complex protein 1 subunit gamma |
Entamoeba histolytica | EHI_158250 | T-complex protein 1 gamma subunit, putative |
Echinococcus multilocularis | EmuJ_000872100 | t complex protein 1 subunit gamma |
Giardia lamblia | GL50803_17411 | TCP-1 chaperonin subunit gamma |
Homo sapiens | ENSG00000163468 | chaperonin containing TCP1, subunit 3 (gamma) |
Leishmania braziliensis | LbrM.23.1320 | T-complex protein 1, gamma subunit, putative |
Leishmania donovani | LdBPK_231460.1 | T-complex protein 1, gamma subunit, putative |
Leishmania infantum | LinJ.23.1460 | T-complex protein 1, gamma subunit, putative |
Leishmania major | LmjF.23.1220 | T-complex protein 1, gamma subunit, putative |
Leishmania mexicana | LmxM.23.1220 | T-complex protein 1, gamma subunit, putative |
Loa Loa (eye worm) | LOAG_11478 | T-complex protein 1 |
Loa Loa (eye worm) | LOAG_01621 | hypothetical protein |
Mus musculus | ENSMUSG00000001416 | chaperonin containing Tcp1, subunit 3 (gamma) |
Neospora caninum | NCLIV_020250 | hypothetical protein |
Oryza sativa | 4341219 | Os06g0538000 |
Oryza sativa | 4328872 | Os02g0247200 |
Plasmodium berghei | PBANKA_1444100 | T-complex protein 1 subunit gamma, putative |
Plasmodium falciparum | PF3D7_1229500 | T-complex protein 1 subunit gamma |
Plasmodium knowlesi | PKNH_1448800 | T-complex protein 1 subunit gamma, putative |
Plasmodium vivax | PVX_124100 | T-complex protein 1 subunit gamma, putative |
Plasmodium yoelii | PY07337 | CCT chaperonin gamma subunit |
Saccharomyces cerevisiae | YJL014W | Cct3p |
Schistosoma japonicum | Sjp_0000740 | ko:K09495 T-complex protein 1 subunit gamma, putative |
Schistosoma japonicum | Sjp_0000730 | T-complex protein 1 subunit gamma, putative |
Schistosoma mansoni | Smp_041740 | chaperonin containing t-complex protein 1 gamma subunit tcpg |
Schmidtea mediterranea | mk4.023824.00 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.011090.02 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.003001.00 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.005078.00 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.023888.02 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.021158.02 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.023824.01 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.017274.01 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.005700.00 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.006034.01 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.014865.00 | T-complex protein 1 subunit gamma |
Schmidtea mediterranea | mk4.000478.07 | T-complex protein 1 subunit gamma |
Trypanosoma brucei gambiense | Tbg972.8.2880 | T-complex protein 1, gamma subunit, putative |
Trypanosoma brucei | Tb927.8.3150 | T-complex protein 1, gamma subunit, putative |
Trypanosoma congolense | TcIL3000_8_3150 | T-complex protein 1, gamma subunit, putative |
Trypanosoma cruzi | TcCLB.504003.60 | chaperonin/T-complex protein 1 gamma subunit, putative |
Toxoplasma gondii | TGME49_205440 | CCT chaperonin gamma subunit |
Theileria parva | TP04_0089 | T-complex protein 1, gamma subunit, putative |
Trichomonas vaginalis | TVAG_029280 | chaperonin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3150 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3150 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3150 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.3150 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F54A3.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F54A3.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F54A3.3 | Caenorhabditis elegans | sterile | wormbase |
YJL014W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1444100 | Plasmodium berghei | Essential | plasmo |
TGME49_205440 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaaca fascicularis | T-complex protein 1 subunit beta | 535 aa | 30.6% | 556 aa | Compounds | References |