pI: 7.0902 |
Length (AA): 300 |
MW (Da): 32851 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128424)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_42810 | MTAP |
Candida albicans | CaO19.14200 | ADH2 expression |
Candida albicans | CaO19.6938 | ADH2 expression |
Caenorhabditis elegans | CELE_B0228.7 | Protein B0228.7 |
Drosophila melanogaster | Dmel_CG4802 | Methylthioadenosine phosphorylase ortholog |
Echinococcus granulosus | EgrG_000622900 | methylthioadenosine phosphorylase |
Echinococcus multilocularis | EmuJ_000622900 | methylthioadenosine phosphorylase |
Homo sapiens | ENSG00000099810 | methylthioadenosine phosphorylase |
Leishmania braziliensis | LbrM.05.0800 | methylthioadenosine phosphorylase, putative |
Leishmania donovani | LdBPK_050830.1 | methylthioadenosine phosphorylase, putative |
Leishmania infantum | LinJ.05.0830 | methylthioadenosine phosphorylase, putative |
Leishmania major | LmjF.05.0830 | methylthioadenosine phosphorylase, putative |
Leishmania mexicana | LmxM.05.0830 | methylthioadenosine phosphorylase, putative |
Loa Loa (eye worm) | LOAG_01831 | S-methyl-5'-thioadenosine phosphorylase MTAP |
Mus musculus | ENSMUSG00000062937 | methylthioadenosine phosphorylase |
Mycobacterium tuberculosis | Rv0535 | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) |
Mycobacterium ulcerans | MUL_0634 | 5'-methylthioadenosine phosphorylase |
Saccharomyces cerevisiae | YLR017W | S-methyl-5-thioadenosine phosphorylase |
Schistosoma japonicum | Sjp_0213000 | ko:K00772 5'-methylthioadenosine phosphorylase [EC2.4.2.28], putative |
Schistosoma mansoni | Smp_102440 | methylthioadenosine phosphorylase |
Schistosoma mansoni | Smp_028190 | methylthioadenosine phosphorylase |
Schmidtea mediterranea | mk4.006248.03 | S-methyl-5'-thioadenosine phosphorylase |
Trypanosoma brucei gambiense | Tbg972.7.8280 | methylthioadenosine phosphorylase, putative |
Trypanosoma brucei | Tb927.7.7040 | methylthioadenosine phosphorylase, putative |
Trypanosoma congolense | TcIL3000_7_5710 | methylthioadenosine phosphorylase, putative |
Trypanosoma cruzi | TcCLB.506789.280 | methylthioadenosine phosphorylase, putative |
Trypanosoma cruzi | TcCLB.508387.20 | methylthioadenosine phosphorylase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.7040 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.7040 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.7040 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.7.7040 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | methylthioadenosine phosphorylase | Compounds | References |
Homo sapiens | methylthioadenosine phosphorylase | Compounds | References |