pI: 7.3558 |
Length (AA): 906 |
MW (Da): 99574 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 905 | 4xgt (A) | 164 | 1103 | 26.00 | 0 | 1 | 1.1823 | 0.38 |
6 | 168 | 2oxc (A) | 72 | 248 | 17.00 | 0 | 1 | 0.399712 | -0.63 |
15 | 901 | 4a4z (A) | 327 | 1280 | 30.00 | 0 | 1 | 1.22533 | 0.39 |
17 | 168 | 3bor (A) | 55 | 219 | 23.00 | 0 | 0.95 | 0.51757 | -0.92 |
18 | 52 | 5v9x (A) | 27 | 61 | 40.00 | 0.075 | 0.91 | 0.493031 | 0.18 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127259)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G70070 | DEAD-box ATP-dependent RNA helicase ISE2 |
Arabidopsis thaliana | AT1G59760 | putative RNA helicase MTR4 |
Arabidopsis thaliana | AT2G06990 | protein HUA ENHANCER 2 |
Babesia bovis | BBOV_II005660 | DSHCT (NUC185) domain containing DEAD/DEAH box helicase family protein |
Brugia malayi | Bm1_42300 | symbol |
Candida albicans | CaO19.1335 | DEAD-box helicase required for mRNA transport, rRNA processing |
Candida albicans | CaO19.8915 | DEAD-box RNA helicase for mRNA export |
Candida albicans | CaO19_1335 | hypothetical protein |
Caenorhabditis elegans | CELE_W08D2.7 | Protein MTR-4 |
Cryptosporidium hominis | Chro.80294 | ATP-dependent RNA helicase; ATP-dependent RNA helicase |
Cryptosporidium parvum | cgd8_2520 | Mtr4p like SKI family SFII helicase |
Dictyostelium discoideum | DDB_G0275633 | DEAD/DEAH box helicase |
Drosophila melanogaster | Dmel_CG4152 | lethal (2) 35Df |
Echinococcus granulosus | EgrG_000456400 | ATP dependent RNA helicase DOB1 |
Echinococcus granulosus | EgrG_000653300 | superkiller viralicidic activity 2 2 |
Entamoeba histolytica | EHI_134610 | DEAD/DEAH box helicase, putative |
Echinococcus multilocularis | EmuJ_000456400 | ATP dependent RNA helicase DOB1 |
Echinococcus multilocularis | EmuJ_000653300 | superkiller viralicidic activity 2 2 |
Giardia lamblia | GL50803_17146 | Helicase |
Homo sapiens | ENSG00000039123 | superkiller viralicidic activity 2-like 2 (S. cerevisiae) |
Leishmania braziliensis | LbrM.35.3220 | ATP-dependent RNA helicase, putative |
Leishmania donovani | LdBPK_363150.1 | ATP-dependent RNA helicase, putative |
Leishmania infantum | LinJ.36.3150 | ATP-dependent RNA helicase, putative |
Leishmania major | LmjF.36.3000 | ATP-dependent RNA helicase, putative |
Leishmania mexicana | LmxM.36.3000 | ATP-dependent RNA helicase, putative |
Loa Loa (eye worm) | LOAG_06429 | hypothetical protein |
Mycobacterium leprae | ML1333 | PROBABLE ATP-DEPENDENT DNA HELICASE HELY |
Mus musculus | ENSMUSG00000016018 | superkiller viralicidic activity 2-like 2 (S. cerevisiae) |
Mycobacterium tuberculosis | Rv2092c | ATP-dependent DNA helicase HelY |
Mycobacterium ulcerans | MUL_2324 | ATP-dependent DNA helicase HelY |
Neospora caninum | NCLIV_013510 | DEAD/DEAH box helicase family protein, related |
Oryza sativa | 4349924 | Os11g0176200 |
Oryza sativa | 4330670 | Os02g0739000 |
Oryza sativa | 9268439 | Os12g0279000 |
Plasmodium berghei | PBANKA_0100900 | ATP-dependent RNA helicase, putative |
Plasmodium falciparum | PF3D7_0602100 | ATP-dependent RNA helicase, putative |
Plasmodium knowlesi | PKNH_1148600 | ATP-dependant RNA helicase, putative |
Plasmodium vivax | PVX_113270 | ATP-dependent RNA helicase, putative |
Plasmodium yoelii | PY01861 | Homo sapiens KIAA0052 protein-related |
Saccharomyces cerevisiae | YJL050W | ATP-dependent RNA helicase MTR4 |
Schistosoma japonicum | Sjp_0313730 | Superkiller viralicidic activity 2-like 2, putative |
Schistosoma japonicum | Sjp_0056690 | ko:K01529 SKIV2L2; superkiller viralicidic activity 2-like 2 [EC:3.6.1.-], putative |
Schistosoma japonicum | Sjp_0112830 | Uncharacterized helicase C6F12.16c, putative |
Schistosoma japonicum | Sjp_0113940 | Superkiller viralicidic activity 2-like 2, putative |
Schistosoma mansoni | Smp_120360 | helicase |
Schistosoma mansoni | Smp_059250 | helicase |
Schmidtea mediterranea | mk4.047824.00 | |
Schmidtea mediterranea | mk4.000260.11 | mRNA transport homolog 4 |
Schmidtea mediterranea | mk4.039813.01 | |
Schmidtea mediterranea | mk4.010718.01 | |
Schmidtea mediterranea | mk4.000260.10 | |
Schmidtea mediterranea | mk4.039813.00 | Uncharacterized helicase |
Schmidtea mediterranea | mk4.010718.00 | Uncharacterized helicase |
Trypanosoma brucei gambiense | Tbg972.10.9120 | ATP-dependent DEAD/H RNA helicase, putative,ATP- dependent RNA helicase, putative |
Trypanosoma brucei | Tb927.10.7440 | ATP-dependent RNA helicase MTR4 |
Trypanosoma congolense | TcIL3000_10_6410 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma cruzi | TcCLB.510105.9 | ATP-dependent DEAD/H RNA helicase, putative |
Toxoplasma gondii | TGME49_213770 | Superkiller viralicidic activity 2 family 2, putative |
Theileria parva | TP02_0517 | hypothetical protein |
Trichomonas vaginalis | TVAG_411940 | activating signal cointegrator 1 complex subunit 3, helc1, putative |
Trichomonas vaginalis | TVAG_309850 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.7440 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.7440 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.7440 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.7440 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_W08D2.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_W08D2.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_W08D2.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_W08D2.7 | Caenorhabditis elegans | sterile | wormbase |
YJL050W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0100900 | Plasmodium berghei | Essential | plasmo |
TGME49_213770 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.