pI: 7.2122 |
Length (AA): 1181 |
MW (Da): 135453 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
13 | 359 | 6gci (A) | 13 | 305 | 20.00 | 0.0000000034 | 1 | 0.855785 | 0.91 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127938)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G27940 | manganese tracking factor for mitochondrial SOD2 |
Arabidopsis thaliana | AT2G46320 | mitochondrial substrate carrier family protein |
Babesia bovis | BBOV_II004390 | mitochondrial carrier protein, putative |
Brugia malayi | Bm1_25200 | Mitochondrial carrier C16C10.1 |
Candida albicans | CaO19.8047 | likely mitochondrial carrier protein similar to S. cerevisiae MTM1 (YGR257C) putative mitochondrial carrier protein implicated i |
Candida albicans | CaO19.417 | likely mitochondrial carrier protein similar to S. cerevisiae MTM1 (YGR257C) putative mitochondrial carrier protein implicated i |
Caenorhabditis elegans | CELE_C16C10.1 | Protein C16C10.1 |
Cryptosporidium hominis | Chro.60444 | mitochondrial carrier |
Cryptosporidium parvum | cgd6_3880 | mitochondrial carrier protein MRS2 with 2 transmembrane domains |
Dictyostelium discoideum | DDB_G0275985 | mitochondrial substrate carrier family protein |
Drosophila melanogaster | Dmel_CG14209 | CG14209 gene product from transcript CG14209-RE |
Drosophila melanogaster | Dmel_CG2616 | CG2616 gene product from transcript CG2616-RB |
Echinococcus granulosus | EgrG_000829400 | solute carrier family 25 0 |
Echinococcus multilocularis | EmuJ_000829400 | solute carrier family 25 0 |
Homo sapiens | ENSG00000075303 | solute carrier family 25, member 40 |
Homo sapiens | ENSG00000013306 | solute carrier family 25, member 39 |
Loa Loa (eye worm) | LOAG_07218 | carrier protein |
Mus musculus | ENSMUSG00000018677 | solute carrier family 25, member 39 |
Mus musculus | ENSMUSG00000054099 | solute carrier family 25, member 40 |
Neospora caninum | NCLIV_064290 | mitochondrial carrier family protein, putative |
Oryza sativa | 4345459 | Os08g0386800 |
Onchocerca volvulus | OVOC8036 | Uncharacterized mitochondrial carrier homolog |
Plasmodium berghei | PBANKA_1005100 | mitochondrial carrier protein, putative |
Plasmodium falciparum | PF3D7_0407500 | mitochondrial carrier protein, putative |
Plasmodium knowlesi | PKNH_0305500 | mitochondrial carrier protein, putative |
Plasmodium vivax | PVX_000870 | mitochondrial carrier protein, putative |
Plasmodium yoelii | PY07641 | Mitochondrial carrier protein, putative |
Saccharomyces cerevisiae | YGR257C | Mtm1p |
Schistosoma japonicum | Sjp_0202610 | Solute carrier family 25 member 40, putative |
Schistosoma mansoni | Smp_137000.2 | mitochondrial carrier protein |
Schistosoma mansoni | Smp_137000.1 | mitochondrial carrier protein |
Schmidtea mediterranea | mk4.004790.01 | Uncharacterized mitochondrial carrier |
Schmidtea mediterranea | mk4.013808.00 | Uncharacterized mitochondrial carrier |
Schmidtea mediterranea | mk4.008047.04 | Uncharacterized mitochondrial carrier |
Toxoplasma gondii | TGME49_248320 | carrier superfamily protein |
Theileria parva | TP04_0552 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C16C10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C16C10.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C16C10.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C16C10.1 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_248320 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.