Detailed view for OVOC9797

Basic information

TDR Targets ID: 988648
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.5159 | Length (AA): 1094 | MW (Da): 123097 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00782  

Gene Ontology

Mouse over links to read term descriptions.
GO:0008138   protein tyrosine/serine/threonine phosphatase activity  
GO:0016791   phosphoric monoester hydrolase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 176 3f81 (A) 11 183 29.00 0 1 1.04819 -0.91
23 181 1yz4 (A) 0 154 42.00 0.000000035 1 1.21568 -1.08
28 168 4yr8 (G) 158 297 35.00 0 1 1.13541 -1.45
99 165 2j16 (A) 124 190 27.00 0.027 0.76 0.55559 0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131563)

Species Accession Gene Product
Brugia malayi Bm1_22010   Dual specificity phosphatase, catalytic domain containing protein
Drosophila melanogaster Dmel_CG10089   CG10089 gene product from transcript CG10089-RE
Echinococcus granulosus EgrG_000933250   dual specificity protein phosphatase
Echinococcus multilocularis EmuJ_000933250   dual specificity protein phosphatase
Giardia lamblia GL50803_15112   Dual specificity phosphatase, catalytic
Homo sapiens ENSG00000149599   dual specificity phosphatase 15
Homo sapiens 100653247   dual specificity protein phosphatase 22-like
Homo sapiens ENSG00000112679   dual specificity phosphatase 22
Loa Loa (eye worm) LOAG_09851   dual specificity phosphatase
Mus musculus ENSMUSG00000042662   dual specificity phosphatase-like 15
Mus musculus ENSMUSG00000069255   dual specificity phosphatase 22
Onchocerca volvulus OVOC9797  
Schistosoma japonicum Sjp_0112130   Dual specificity protein phosphatase 22-A, putative
Schistosoma japonicum Sjp_0054200   IPR000340,Dual specificity protein phosphatase,domain-containing
Schistosoma mansoni Smp_169960   dual specificity protein phosphatase
Schmidtea mediterranea mk4.001591.01   Dual specificity protein phosphatase 22
Schmidtea mediterranea mk4.000083.11  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens dual specificity phosphatase 15 Compounds References
Homo sapiens dual specificity phosphatase 22 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Sodium/potassium-transporting ATPase alpha-1 chain 1021 aa 30.1% 1097 aa Compounds References
Rattus norvegicus Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 994 aa 26.5% 905 aa Compounds References
Sus scrofa Potassium-transporting ATPase alpha chain 1 1034 aa 29.3% 1064 aa Compounds References
Rattus norvegicus Potassium-transporting ATPase 1033 aa 29.5% 1060 aa Compounds References
Canis lupus familiaris Sodium/potassium-transporting ATPase alpha-1 chain 1021 aa 29.7% 1098 aa Compounds References
Rattus norvegicus Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1043 aa 25.0% 1043 aa Compounds References
Rattus norvegicus Sodium/potassium-transporting ATPase alpha-1 chain 1023 aa 30.0% 1072 aa Compounds References
Oryctolagus cuniculus Sarcoplasmic/endoplasmic reticulum calcium ATP-ase 1001 aa 26.5% 925 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0953 0.5 0.5
0.1504 0.3887 1
0.0198 0.3029 1
0.0198 0.4429 1
0.0486 0.3032 1
0.1024 0.2847 1
0.0988 0.7072 1
0.144 0.4665 1
0.0819 0.4202 1
0.0184 0.4384 1
0.0476 0.5002 1
0.0395 0.4858 1
0.1011 0.5753 1
0.1331 0.3146 0.9696
0.1187 0.2746 1
0.0987 0.4126 1
0.0172 0.2945 1
0.0198 0.4398 1
0.0653 0.3533 0.9236
0.0198 0.438 1
0.1004 0.7381 1
0.1393 0.286 1
0.1127 1 1
0.0709 0.2615 1
0.0815 0.4591 1
0.0817 0.3756 1
0.1158 0.3252 1
0.0323 0.354 1
0.0198 0.3481 1
0.0272 0.4217 1
0.1384 0.6822 1
0.0198 0.5 0.5
0.0867 0.2709 1
0.1502 0.3375 1
0.1142 0.4101 1
0.0819 0.4202 1
0.182 1 1
0.0486 0.3539 1
0.0653 0.3533 0.9236
0.0821 0.5148 0.5
0.0323 0.3906 1
0.0391 0.3931 1
0.0813 0.6868 1
0.0655 0.3103 1
0.0198 0.438 1
0.0562 0.6057 1
0.0198 0.5 0.5
0.0323 0.3968 0.5
0.0902 1 1
0.069 0.252 1
0.1495 0.8743 1
0.0652 0.4589 1
0.0821 0.5148 0.5
0.1495 1 1
0.0323 0.3968 0.5
0.0198 0.2637 1
0.0567 0.5772 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier OVOC9797 (Onchocerca volvulus),
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