Detailed view for OVOC8058

Basic information

TDR Targets ID: 989890
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.9407 | Length (AA): 65 | MW (Da): 7703 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09360  

Gene Ontology

Mouse over links to read term descriptions.
GO:0051537   2 iron, 2 sulfur cluster binding  
GO:0043231   intracellular membrane-bounded organelle  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
63 147 3tbn (A) 0 77 45.00 0 0.82 1.00117 -0.39
67 156 6avj (A) 36 121 40.00 0.000000000007 0.95 1.06585 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131688)

Species Accession Gene Product
Babesia bovis BBOV_II006940   hypothetical protein
Brugia malayi Bm1_45735   RE40412p
Brugia malayi Bm1_09040   RE40412p
Caenorhabditis elegans CELE_M88.7   Protein M88.7
Caenorhabditis elegans CELE_Y67D2.3   Protein Y67D2.3
Dictyostelium discoideum DDB_G0274303   hypothetical protein
Dictyostelium discoideum DDB_G0267712   hypothetical protein
Drosophila melanogaster Dmel_CG3420   CG3420 gene product from transcript CG3420-RA
Echinococcus granulosus EgrG_000627020   conserved hypothetical protein
Echinococcus multilocularis EmuJ_000627020   conserved hypothetical protein
Homo sapiens 284106   CDGSH iron sulfur domain 3
Leishmania braziliensis LbrM.34.1290   hypothetical protein, unknown function
Leishmania donovani LdBPK_351380.1   Iron-binding zinc finger CDGSH type, putative
Leishmania infantum LinJ.35.1380   hypothetical protein, unknown function
Leishmania major LmjF.35.1370   hypothetical protein, unknown function
Leishmania mexicana LmxM.34.1370   hypothetical protein, unknown function
Loa Loa (eye worm) LOAG_11864   hypothetical protein
Loa Loa (eye worm) LOAG_04015   hypothetical protein
Mus musculus 100504524   predicted gene, 20267
Mus musculus ENSMUSG00000078695   CDGSH iron sulfur domain 3
Neospora caninum NCLIV_008340   AGAP004885-PA, related
Onchocerca volvulus OVOC7879  
Onchocerca volvulus OVOC8058  
Plasmodium berghei PBANKA_0507100   CDGSH iron-sulfur domain-containing protein, putative
Plasmodium falciparum PF3D7_1022900   CDGSH iron-sulfur domain-containing protein, putative
Plasmodium knowlesi PKNH_0607200   CDGSH iron-sulfur domain-containing protein, putative
Plasmodium vivax PVX_111570   hypothetical protein, conserved
Plasmodium yoelii PY01665   hypothetical protein
Schistosoma japonicum Sjp_0066920   ko:K00271 putative glutamate synthetas [EC:1.4.1.-], putative
Schistosoma japonicum Sjp_0066910   IPR012336,Thioredoxin-like fold,domain-containing
Schistosoma mansoni Smp_157700   hypothetical protein
Toxoplasma gondii TGME49_254030   zinc finger CDGSH-type domain-containing protein

Essentiality

OVOC8058 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0507100 Plasmodium berghei Essential plasmo
TGME49_254030 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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