Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4906 | 0.4782 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.4906 | 0.4906 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4906 | 0.4782 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.054 | 0.054 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0123 | 0.5661 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.4906 | 0.2701 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.4906 | 0.4615 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4906 | 0.4782 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.5661 | 0.5414 |
Echinococcus multilocularis | pyruvate kinase | 0.014 | 0.6979 | 0.5671 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.054 | 0.054 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4906 | 0.4782 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4906 | 0.4782 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0123 | 0.5661 | 0.5414 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4906 | 0.4782 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.4906 | 0.4782 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.4906 | 0.4716 |
Schistosoma mansoni | pyruvate kinase | 0.0091 | 0.3021 | 0.2761 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.4906 | 0.2701 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.4906 | 0.2701 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.003 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.