Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | < 4 | Cytotoxicity against human KB cells after 48 hrs by SRB | ChEMBL. | 20667627 |
GI50 (functional) | < 4 | Cytotoxicity against human PC3 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
GI50 (functional) | < 4 | Cytotoxicity against human HepG2 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
GI50 (functional) | < 4 | Cytotoxicity against human K562 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
GI50 (functional) | = 4.53 | Cytotoxicity against human HOP62 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
GI50 (functional) | = 4.55 | Cytotoxicity against human MCF7 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
TGI (functional) | < 4 | Cytotoxicity against human KB cells after 48 hrs by SRB | ChEMBL. | 20667627 |
TGI (functional) | < 4 | Cytotoxicity against human PC3 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
TGI (functional) | < 4 | Cytotoxicity against human HOP62 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
TGI (functional) | < 4 | Cytotoxicity against human HepG2 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
TGI (functional) | < 4 | Cytotoxicity against human MCF7 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
TGI (functional) | < 4 | Cytotoxicity against human K562 cells after 48 hrs by SRB | ChEMBL. | 20667627 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.