Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intermediate filament protein | 0.0033 | 0.3959 | 0.3959 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.3959 | 0.3959 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.5946 | 0.7168 |
Schistosoma mansoni | lamin | 0.0033 | 0.3959 | 0.4757 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.0033 | 0.3959 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.8278 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.5946 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.5946 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.3959 | 0.4757 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.5946 | 0.7168 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.8278 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.8278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3803 | 0.3803 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.3959 | 0.4757 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3959 | 0.3959 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0041 | 0.0041 |
Onchocerca volvulus | 0.0033 | 0.3959 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.8278 | 0.8278 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.8278 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.3959 | 0.3959 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.5946 | 0.7168 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.5946 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.3959 | 0.4757 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.539 | 0.539 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.539 | 0.539 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.3959 | 0.4757 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.5946 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.8278 | 0.8278 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0041 | 0.0041 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.3959 | 0.4757 |
Echinococcus multilocularis | musashi | 0.0033 | 0.3959 | 0.4757 |
Echinococcus multilocularis | lamin | 0.0033 | 0.3959 | 0.4757 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.8278 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.3959 | 0.3959 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.8278 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.5946 | 0.7168 |
Brugia malayi | hypothetical protein | 0.004 | 0.5946 | 0.5946 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.539 | 0.6494 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0041 | 0.0041 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.8278 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.3959 | 0.4757 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 98.008295 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Inhibition (ADMET) | = 116.4446926 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.