Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0055 | 0.0296 | 0.0896 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0277 | 0.2894 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0501 | 0.55 | 0.55 |
Leishmania major | DNA topoisomerase ii | 0.0223 | 0.2258 | 0.7549 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.1189 | 0.3604 |
Brugia malayi | Probable DNA topoisomerase II | 0.0277 | 0.2894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0813 | 0.2463 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0055 | 0.0296 | 0.1022 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1104 | 0.3345 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0223 | 0.2258 | 0.78 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0501 | 0.55 | 0.5362 |
Schistosoma mansoni | hypothetical protein | 0.0312 | 0.33 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0277 | 0.2894 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0253 | 0.2615 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0501 | 0.55 | 0.5362 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1663 | 0.504 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0055 | 0.0296 | 0.0296 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0055 | 0.0296 | 0.0896 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0055 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.1189 | 0.3604 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0055 | 0.0296 | 0.0896 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0501 | 0.55 | 0.5362 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0277 | 0.2894 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0277 | 0.2894 | 0.8772 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0312 | 0.33 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0277 | 0.2894 | 1 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0055 | 0.0296 | 0.1022 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0277 | 0.2894 | 0.8772 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0055 | 0.0296 | 0.0296 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0388 | 0.4185 | 1 |
Echinococcus granulosus | geminin | 0.0172 | 0.1663 | 0.504 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0277 | 0.2894 | 0.2894 |
Brugia malayi | DNA topoisomerase III | 0.0055 | 0.0296 | 0.1022 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0277 | 0.2894 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0277 | 0.2894 | 1 |
Brugia malayi | GRF zinc finger family protein | 0.0055 | 0.0296 | 0.1022 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0223 | 0.2258 | 0.7549 |
Schistosoma mansoni | DNA topoisomerase II | 0.0277 | 0.2894 | 0.8772 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0099 | 0.0813 | 0.0533 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1663 | 0.504 |
Echinococcus granulosus | snurportin 1 | 0.0312 | 0.33 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1104 | 0.3345 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0277 | 0.2894 | 0.8772 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.1189 | 0.4109 |
Echinococcus multilocularis | snurportin 1 | 0.0312 | 0.33 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0277 | 0.2894 | 0.2894 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0277 | 0.2894 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0501 | 0.55 | 0.55 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0277 | 0.2894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0813 | 0.2463 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0055 | 0.0296 | 0.0896 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0055 | 0.0296 | 0.1022 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0055 | 0.0296 | 0.0896 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0223 | 0.2258 | 0.7549 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0223 | 0.2258 | 0.78 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0277 | 0.2894 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0277 | 0.2894 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 0.1663 | 0.504 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0277 | 0.2894 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.0629 | 0.2172 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0055 | 0.0296 | 0.0896 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0055 | 0.0296 | 0.0896 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0055 | 0.0296 | 0.0896 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0501 | 0.55 | 0.5362 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0055 | 0.0296 | 0.1022 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0501 | 0.55 | 0.5362 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0277 | 0.2894 | 0.2894 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0055 | 0.0296 | 0.0296 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0179 | 0.1741 | 0.1741 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.98 | Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay | ChEMBL. | 21375334 |
IC50 (binding) | = 105 uM | Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay | ChEMBL. | 21375334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.