Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | porcupine homolog (Drosophila) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus multilocularis | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus granulosus | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Loa Loa (eye worm) | MBOAT family protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Brugia malayi | MBOAT family protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Schistosoma japonicum | ko:K00181 porcupine, putative | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0512 | 0.1161 | 0.5 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0299 | 0.0126 | 0.1082 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0512 | 0.1161 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0512 | 0.1161 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0512 | 0.1161 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0877 | 0.2942 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0877 | 0.2942 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0512 | 0.1161 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.1108 | 0.407 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1123 | 0.4144 | 0.3374 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0299 | 0.0126 | 0.1082 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1123 | 0.4144 | 0.3374 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1123 | 0.4144 | 0.2332 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0877 | 0.2942 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0512 | 0.1161 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0512 | 0.1161 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0512 | 0.1161 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0877 | 0.2942 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0475 | 0.0985 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0512 | 0.1161 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0512 | 0.1161 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0636 | 0.1766 | 0.0684 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0512 | 0.1161 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0512 | 0.1161 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 1 uM | Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay | ChEMBL. | 23477365 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.