Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2218 | 0.3289 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0013 | 0.0002 | 0.0002 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0013 | 0.0002 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0013 | 0.0002 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0097 | 0.6742 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0013 | 0.0002 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0097 | 0.6742 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0041 | 0.2218 | 0.3289 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0097 | 0.6742 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0013 | 0.0002 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0028 | 0.1191 | 0.1767 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.1191 | 0.1191 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0013 | 0.0002 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0041 | 0.2218 | 0.3289 |
Brugia malayi | Isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0013 | 0.0002 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0013 | 0.0002 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0013 | 0.0002 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0041 | 0.2218 | 0.3289 |
Brugia malayi | isocitrate dehydrogenase | 0.0013 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1191 | 0.1767 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 4.9 % | Agonist activity at mouse androgen receptor at 10 uM after 24 hrs by cell-based luciferase reporter gene assay relative to control | ChEMBL. | 23527816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.