Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.015 | 0.2022 | 0.2022 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0.3182 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0164 | 0.3182 | 0.3182 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | hypothetical protein | 0.015 | 0.2022 | 0.2022 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0164 | 0.3182 | 0.3182 |
Schistosoma mansoni | loxhd1 | 0.015 | 0.2022 | 0.2022 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | Cathepsin L-like precursor | 0.0164 | 0.3182 | 0.3182 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.015 | 0.2022 | 0.2022 |
Echinococcus granulosus | cathepsin l1 | 0.0164 | 0.3182 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3182 | 0.1454 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.015 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3182 | 0.1454 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0164 | 0.3182 | 0.3182 |
Schistosoma mansoni | rab6-interacting | 0.015 | 0.2022 | 0.2022 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.015 | 0.2022 | 0.2022 |
Plasmodium falciparum | LCCL domain-containing protein | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | hypothetical protein | 0.015 | 0.2022 | 0.2022 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.015 | 0.2022 | 0.2022 |
Echinococcus granulosus | RUN | 0.015 | 0.2022 | 0.2022 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | cathepsin L-like precursor | 0.0164 | 0.3182 | 0.3182 |
Echinococcus multilocularis | RUN | 0.015 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3182 | 0.1454 |
Schistosoma mansoni | lipoxygenase | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | Doublecortin family protein | 0.015 | 0.2022 | 0.2022 |
Onchocerca volvulus | 0.0164 | 0.3182 | 0.1454 | |
Brugia malayi | Cathepsin L-like precursor | 0.0164 | 0.3182 | 0.3182 |
Schistosoma mansoni | polycystin 1-related | 0.015 | 0.2022 | 0.2022 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0164 | 0.3182 | 0.3182 |
Schistosoma mansoni | rab6-interacting | 0.015 | 0.2022 | 0.2022 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0164 | 0.3182 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FC (binding) | = 0.43 | Induction of HEXIM1 protein expression in human LNCAP cells at 100 uM after 24 hrs by Western blotting analysis relative to control | ChEMBL. | 24503105 |
FC (binding) | = 3.09 | Induction of HEXIM1 protein expression in human LNCAP cells at 500 uM after 24 hrs by Western blotting analysis relative to control | ChEMBL. | 24503105 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.