Target list

Search results for query: Weighted ranking of Pfa targets (plastid associated) for PLOS-NTD

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #236 (Pfa any essentiality): 50
  • Score for genes in query #242 (Pfa Pubmed): -20
  • Score for genes in query #235 (Pfa Enzymes (EC + functional category)): 100
  • Score for genes in query #237 (Pfa all proteins): 1
  • Score for genes in query #251 (Curated list of nuclear encode apicoplast targeted gene from Stuart Ralph): 1000
  • Score for genes in query #249 (Pfa assayable): 20
  • Score for genes in query #241 (Pfa compound desirability >0.2): 10
  • Score for genes in query #246 (Pfa ortholog in taxon (Pvi)): 50
  • Score for genes in query #244 (Pfa Modbase structure models): 10
  • Score for genes in query #248 (Pfa Dindex >=0.4): 20
  • Score for genes in query #245 (Pfa NOT in humans): 50
  • Score for genes in query #239 (Pfa uploaded weighted list for Isoelectric point): 0
  • Score for genes in query #247 (Pfa any genetic validation): -50
  • Score for genes in query #243 (Pfa PDB structures): -100
  • Score for genes in query #240 (Pfa uploaded weighted list for molecular weight): 0
  • Score for genes in query #238 (Pfa expression in any RBC stage (80-100%)): 25

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

4804 records found | Showing page 193 of 193 (records 4801-4804) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
P. falciparum   PF3D7_1219700   OG5_127642   raf kinase inhibitor -39
P. falciparum   PF3D7_0729200   OG5_127915   1-cys peroxiredoxin -59
P. falciparum   PF3D7_0731500   OG5_148188   erythrocyte binding antigen-175 -59
P. falciparum   PF3D7_0916100   OG5_141346   thioredoxin 3 -59

Showing page 193 (records 4801-4804) of 193