Target list

Search results for query: union of pfal genes w/ >0.8 dindex (20), no mammalian orthologs (10) & eny w/ any essentiality data (30)

  • Score for genes in query #3 (pfal genes w/ no mammalian orthologs): 10
  • Score for genes in query #2 (pfal gene w/ high dindex (>0.8)): 20
  • Score for genes in query #1 (pfal enz w/ any essentiality data): 30

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

3356 records found | Showing page 2 of 135 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
P. falciparum   PF3D7_0417200   OG5_127385   bifunctional dihydrofolate reductase-thymidylate synthase 50
P. falciparum   PF3D7_0509800   OG5_127682   phosphatidylinositol 4-kinase 50
P. falciparum   PF3D7_0510500   OG5_127702   topoisomerase I 50
P. falciparum   PF3D7_0630300   OG5_127942   DNA polymerase epsilon catalytic subunit A, putative 50
P. falciparum   PF3D7_0920800   OG5_126887   inosine-5'-monophosphate dehydrogenase 50
P. falciparum   PF3D7_1206600   OG5_126694   DNA-directed RNA polymerase III subunit RPC2, putative 50
P. falciparum   PF3D7_1246900   OG5_126635   RAC-beta serine/threonine protein kinase 50
P. falciparum   PF3D7_1247500   OG5_127425   serine/threonine protein kinase, putative 50
P. falciparum   PF3D7_1343000   OG5_132295   phosphoethanolamine N-methyltransferase 40
P. falciparum   PF3D7_0716600   OG5_128800   cysteine desulfurase 40
P. falciparum   PF3D7_0810800   OG5_128803   hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase 40
P. falciparum   PF3D7_1022800   OG5_130276   4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 40
P. falciparum   PF3D7_1323000   OG5_130367   beta-hydroxyacyl-ACP dehydratase 40
P. falciparum   PF3D7_1327600   OG5_131883   nicotinamide/nicotinic acid mononucleotide adenylyltransferase 40
P. falciparum   PF3D7_1332600   OG5_129467   apurinic/apyrimidinic endonuclease Apn1, putative 40
P. falciparum   PF3D7_1435300   OG5_126892   NAD(P)H-dependent glutamate synthase, putative 40
P. falciparum   PF3D7_1467300   OG5_130462   1-deoxy-D-xylulose 5-phosphate reductoisomerase 40
P. falciparum   PF3D7_0104400   OG5_130373   4-hydroxy-3-methylbut-2-enyl diphosphate reductase 40
P. falciparum   PF3D7_0209300   OG5_130616   2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 40
P. falciparum   PF3D7_0211400   OG5_129509   beta-ketoacyl-ACP synthase III 40
P. falciparum   PF3D7_0219500   OG5_128305   pseudouridine synthase, putative 40
P. falciparum   PF3D7_0420200   OG5_130884   holo-[acyl-carrier-protein] synthase, putative 40
P. falciparum   PF3D7_0503100   OG5_130885   4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 40
P. falciparum   PF3D7_0520500   OG5_128612   phosphomethylpyrimidine kinase, putative 40
P. falciparum   PF3D7_0623000   OG5_128304   chorismate synthase 40

Showing page 2 (records 26-50) of 135