Target list

Search results for query: Wes VV TB Prioritized Targets: Structure, Enzyme, <600AA, essential, curated, not in human

  • Score for genes in query #52 (TB enzymes (any EC #)): 35
  • Score for genes in query #54 (TB < 600 AA): 25
  • Score for genes in query #61 (TB E coli essentials): 20
  • Score for genes in query #59 (TB with Modeled structures): 20
  • Score for genes in query #62 (TB essential in any species): 10
  • Score for genes in query #48 (TB curated): 50
  • Score for genes in query #58 (TB w/ solved structures): 30
  • Score for genes in query #63 (TB not in human): 10
  • Score for genes in query #60 (TB known essentials): 35

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2250 records found | Showing page 4 of 90 (records 76-100) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0014c   OG5_146588   Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 140
M. tuberculosis   Rv2043c   OG5_127752   Pyrazinamidase/nicotinamidase PncA (PZase) 140
M. tuberculosis   Rv1849   OG5_145075   Urease beta subunit UreB (urea amidohydrolase) 140
M. tuberculosis   Rv2538c   OG5_127183   3-dehydroquinate synthase AroB 135
M. tuberculosis   Rv2552c   OG5_128849   Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) 135
M. tuberculosis   Rv0766c   OG5_132455   Probable cytochrome P450 123 Cyp123 135
M. tuberculosis   Rv2266   OG5_132455   Probable cytochrome P450 124 Cyp124 135
M. tuberculosis   Rv2268c   OG5_132455   Probable cytochrome P450 128 Cyp128 135
M. tuberculosis   Rv1256c   OG5_132455   Probable cytochrome P450 130 Cyp130 135
M. tuberculosis   Rv3518c   OG5_132455   Probable cytochrome P450 monooxygenase 142 Cyp142 135
M. tuberculosis   Rv2392   OG5_129962   Probable 3'-phosphoadenosine 5'-phosphosulfate reductase CysH (PAPS reductase, t ... 135
M. tuberculosis   Rv3132c   OG5_153508   Two component sensor histidine kinase DevS 135
M. tuberculosis   Rv2500c   OG5_128729   Possible acyl-CoA dehydrogenase FadE19 (MMGC) 135
M. tuberculosis   Rv3564   OG5_156898   Probable acyl-CoA dehydrogenase FadE33 135
M. tuberculosis   Rv3858c   OG5_126892   Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate syn ... 135
M. tuberculosis   Rv1601   OG5_129258   Probable imidazole glycerol-phosphate dehydratase HisB 135
M. tuberculosis   Rv1600   OG5_127656   Probable histidinol-phosphate aminotransferase HisC1 135
M. tuberculosis   Rv1606   OG5_131046   Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI 135
M. tuberculosis   Rv0085   OG5_147565   Possible hydrogenase HycP 135
M. tuberculosis   Rv3383c   OG5_130660   Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosp ... 135
M. tuberculosis   Rv3001c   OG5_129100   Probable KETOL-acid reductoisomerase IlvC (acetohydroxy-acid isomeroreductase) ( ... 135
M. tuberculosis   Rv3002c   OG5_129345   Probable acetolactate synthase (small subunit) IlvN (acetohydroxy-acid synthase) ... 135
M. tuberculosis   Rv2987c   OG5_130205   Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate iso ... 135
M. tuberculosis   Rv1614   OG5_132435   Possible prolipoprotein diacylglyceryl transferases Lgt 135
M. tuberculosis   Rv3341   OG5_131823   Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (hom ... 135

Showing page 4 (records 76-100) of 90