Target list

Search results for query: Wes VV TB Prioritized Targets: Structure, Enzyme, <600AA, essential, curated, not in human

  • Score for genes in query #48 (TB curated): 50
  • Score for genes in query #58 (TB w/ solved structures): 30
  • Score for genes in query #54 (TB < 600 AA): 25
  • Score for genes in query #60 (TB known essentials): 35
  • Score for genes in query #61 (TB E coli essentials): 20
  • Score for genes in query #59 (TB with Modeled structures): 20
  • Score for genes in query #63 (TB not in human): 10
  • Score for genes in query #52 (TB enzymes (any EC #)): 35
  • Score for genes in query #62 (TB essential in any species): 10

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2250 records found | Showing page 5 of 90 (records 101-125) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0982   OG5_138524   Two component sensor kinase MprB 135
M. tuberculosis   Rv2855   OG5_126785   NADPH-dependent mycothiol reductase Mtr 135
M. tuberculosis   Rv3245c   OG5_137864   Two component sensory transduction histidine kinase MtrB 135
M. tuberculosis   Rv3886c   OG5_159793   Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protea ... 135
M. tuberculosis   Rv0291   OG5_149677   Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like prot ... 135
M. tuberculosis   Rv3449   OG5_159793   Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like prot ... 135
M. tuberculosis   Rv1796   OG5_237702   Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtili ... 135
M. tuberculosis   Rv3490   OG5_129327   Alpha, alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosph ... 135
M. tuberculosis   Rv0758   OG5_128582   Possible two component system response sensor kinase membrane associated PhoR 135
M. tuberculosis   Rv0015c   OG5_155711   Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) 135
M. tuberculosis   Rv1743   OG5_142551   Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) ... 135
M. tuberculosis   Rv1746   OG5_144303   Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK ... 135
M. tuberculosis   Rv2914c   OG5_142551   Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) ... 135
M. tuberculosis   Rv2702   OG5_164841   Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) 135
M. tuberculosis   Rv2439c   OG5_129344   Probable glutamate 5-kinase protein ProB (gamma-glutamyl kinase) (GK) 135
M. tuberculosis   Rv0780   OG5_131443   Phosphoribosylaminoimidazole- succinocarboxamide synthase PurC (SAICAR synthetas ... 135
M. tuberculosis   Rv3275c   OG5_127668   Probable phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air ca ... 135
M. tuberculosis   Rv2671   OG5_208947   Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydrox ... 135
M. tuberculosis   Rv1409   OG5_127122   Probable bifunctional riboflavin biosynthesis protein RibG : diaminohydroxyphosp ... 135
M. tuberculosis   Rv0334   OG5_131815   Alpha-D-glucose-1-phosphate thymidylyltransferase RmlA (dTDP-glucose synthase) ( ... 135
M. tuberculosis   Rv0208c   OG5_127179   Hypothetical methlytransferase (methylase) 135
M. tuberculosis   Rv0517   OG5_162561   Possible membrane acyltransferase 135
M. tuberculosis   Rv0526   OG5_129566   Possible thioredoxin protein (thiol-disulfide interchange protein) 135
M. tuberculosis   Rv1188   OG5_171183   Probable proline dehydrogenase 135
M. tuberculosis   Rv1254   OG5_208500   Probable acyltransferase 135

Showing page 5 (records 101-125) of 90