Detailed view for Rv1112

Basic information

TDR Targets ID: 981498
Mycobacterium tuberculosis, Probable GTP binding protein
Source Database / ID:  Tuberculist 

pI: 4.5402 | Length (AA): 357 | MW (Da): 38065 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01926  
PF06071  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 357 1jal (A) 1 363 52.00 0 1 1.5366 -0.03
2 42 2wji (A) 3 43 56.00 0.022 0.27 0.474546 0.9
3 47 4q00 (A) 4 58 42.00 0.53 0.47 0.45975 -0.04
3 356 2dwq (B) 2 367 47.00 0 1 1.36 0.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126949)

Species Accession Gene Product
Arabidopsis thaliana AT1G30580   GTP-binding protein
Arabidopsis thaliana AT1G56050   putative GTP-binding protein
Babesia bovis BBOV_III002190   GTP-binding protein YchF domain containing protein
Brugia malayi Bm1_49455   GTP-binding protein W08E3.3
Candida albicans CaO19.754   GTP-binding protein
Candida albicans CaO19.8374   GTP-binding protein
Caenorhabditis elegans CELE_W08E3.3   Protein OLA-1, isoform B
Cryptosporidium hominis Chro.10311   GTP-binding protein
Cryptosporidium parvum cgd1_2760   yyaF/YCHF TRANSFAC/OBG family small GTpase plus RNA binding domain TGS
Chlamydia trachomatis CT_092   GTPase
Dictyostelium discoideum DDB_G0268758   hypothetical protein
Dictyostelium discoideum DDB_G0292626   hypothetical protein
Drosophila melanogaster Dmel_CG1354   CG1354 gene product from transcript CG1354-RD
Escherichia coli b1203   catalase inhibitor protein
Echinococcus granulosus EgrG_000677800   GTP binding protein CG1354
Entamoeba histolytica EHI_148270   GTP-binding protein, putative
Echinococcus multilocularis EmuJ_000677800   GTP binding protein CG1354
Giardia lamblia GL50803_114246   GTP-binding protein, putative
Homo sapiens ENSG00000138430   Obg-like ATPase 1
Leishmania braziliensis LbrM.27.2520   GTP binding protein, putative
Leishmania donovani LdBPK_272260.1   GTP binding protein, putative
Leishmania infantum LinJ.27.2260   GTP binding protein, putative
Leishmania major LmjF.27.2330   GTP binding protein, putative
Leishmania mexicana LmxM.27.2330   GTP binding protein, putative
Loa Loa (eye worm) LOAG_01579   GTP-binding protein
Mycobacterium leprae ML1936c   Probable GTP binding protein
Mus musculus ENSMUSG00000027108   Obg-like ATPase 1
Mycobacterium tuberculosis Rv1112   Probable GTP binding protein
Mycobacterium ulcerans MUL_0166   GTP-dependent nucleic acid-binding protein EngD
Neospora caninum NCLIV_051590   GTP binding protein, putative
Oryza sativa 9269534   Os03g0781000
Oryza sativa 4344894   Os08g0199300
Plasmodium berghei PBANKA_0619900   Obg-like ATPase 1, putative
Plasmodium falciparum PF3D7_0722400   Obg-like ATPase 1, putative
Plasmodium knowlesi PKNH_0317800   Obg-like ATPase 1, putative
Plasmodium vivax PVX_096235   GTP-binding protein, putative
Plasmodium yoelii PY02266   GTP-binding protein
Saccharomyces cerevisiae YBR025C   Ola1p
Schistosoma japonicum Sjp_0214350   ko:K06942 OLA1; Obg-like ATPase 1, putative
Schistosoma mansoni Smp_015720   GTP-binding protein-related
Schmidtea mediterranea mk4.034045.05  
Trypanosoma brucei gambiense Tbg.972.2.3080   GTP binding protein, putative
Trypanosoma brucei Tb927.2.5060   GTP binding protein, putative
Trypanosoma congolense TcIL3000_2_1210   GTP binding protein, putative
Trypanosoma cruzi TcCLB.511625.50   GTP-binding protein, putative
Trypanosoma cruzi TcCLB.504741.20   GTP-binding protein, putative
Toxoplasma gondii TGME49_214350   GTP-binding protein, putative
Treponema pallidum TP0124   GTP-dependent nucleic acid-binding protein EngD
Theileria parva TP03_0578   GTP-binding protein, putative
Trichomonas vaginalis TVAG_016670   GTP-binding protein, putative
Wolbachia endosymbiont of Brugia malayi Wbm0159   GTP-dependent nucleic acid-binding protein EngD

Essentiality

Rv1112 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.5060 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.5060 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.2.5060 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.5060 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_W08E3.3 Caenorhabditis elegans embryonic lethal wormbase
TGME49_214350 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv1112 (Mycobacterium tuberculosis), Probable GTP binding protein
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